PXD039001

PXD039001 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices
Description	The vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poorly studied. The lncRNA H19 mediates osteogenic differentiation of Mesenchymal Stem/Stromal Cells (MSCs) through the control of intracellular pathways. However, the effect of H19 on the extracellular matrix (ECM) components is still largely unknown. This research study was designed to decode the H19-mediated ECM regulatory network, and to reveal how the decellularized siH19-engineered matrices influence MSC proliferation and fate. This is particularly relevant for diseases in which the ECM regulation and remodelling processes are disrupted, such as osteoporosis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:43:59.369.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD039001
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Hugo Osorio
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-20 20:33:17	ID requested
1	2023-03-11 11:16:24	announced
⏵ 2	2023-11-14 08:44:07	announced	2023-11-14: Updated project metadata.

Publication List

10.6019/PXD039001;
Moura SR, Freitas J, Ribeiro-Machado C, Lopes J, Neves N, Canh, ã, o H, Rodrigues AM, Barbosa MA, Almeida MI, Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices. Stem Cell Res Ther, 14(1):37(2023) [pubmed]

10.6019/PXD039001;

Moura SR, Freitas J, Ribeiro-Machado C, Lopes J, Neves N, Canh, ã, o H, Rodrigues AM, Barbosa MA, Almeida MI, Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices. Stem Cell Res Ther, 14(1):37(2023) [pubmed]

Keyword List

submitter keyword: non-coding RNAs
fragility fractures
bone extracellular matrix
gene therapy
decellularization

submitter keyword: non-coding RNAs

fragility fractures

bone extracellular matrix

gene therapy

decellularization

Contact List

Ines Almeida
contact affiliation	1) Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal 2) Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal 3) Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
contact email	ines.almeida@ineb.up.pt
lab head
Hugo Osorio
contact affiliation	i3S - Institute for Research and Innovation in Health, University of Porto
contact email	hosorio@i3s.up.pt
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD039001
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD039001

PRIDE project URI

Repository Record List

[ + ]