PXD038996

PXD038996 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Global phospho-proteomics analysis of the effect of CD25 KO in precursor and mature B-cell
Description	To assess the effect of CD25 (Il2ra) knockout on signaling in pre-B leukemia, pre-B cells from CD25-floxed mouse bone marrow were grown ex-vivo with IL-7 and transformed with BCR-ABL1, before treatment with 4-OHT to induce CD25 KO. Phosphoproteomics was performed and differential phosphosites analysed in Cre-ERT2 vs ERT2 samples.
HostingRepository	PRIDE
AnnounceDate	2026-02-23
AnnouncementXML	Submission_2026-02-22_16:49:58.126.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mark Robinson
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-20 20:13:54	ID requested
⏵ 1	2026-02-22 16:49:59	announced

Publication List

Lee J, Sun R, Kume K, Robinson ME, Cheng Z, Cosgun KN, Ma N, Hurtz C, Geng H, Luger SM, Litzow MR, Paietta E, Chen J, Vaidehi N, M, ü, schen M, Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia. Sci Signal, 19(924):eadw5054(2026) [pubmed]
10.1126/scisignal.adw5054;

Lee J, Sun R, Kume K, Robinson ME, Cheng Z, Cosgun KN, Ma N, Hurtz C, Geng H, Luger SM, Litzow MR, Paietta E, Chen J, Vaidehi N, M, ü, schen M, Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia. Sci Signal, 19(924):eadw5054(2026) [pubmed]

10.1126/scisignal.adw5054;

Keyword List

submitter keyword: B-cell pre-B CD25 Il2ra phospho-proteomics

submitter keyword: B-cell pre-B CD25 Il2ra phospho-proteomics

Contact List

Marcus Muschen
contact affiliation	Yale University
contact email	markus.muschen@yale.edu
lab head
Mark Robinson
contact affiliation	Center of Molecular and Cellular Oncology, Yale University
contact email	mark.robinson@yale.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD038996
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD038996

PRIDE project URI

Repository Record List

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