PXD038983

PXD038983 is an original dataset announced via ProteomeXchange.

Title	Post-transcriptional control of a stemness signature by RNA-binding 8 protein MEX3A regulates adult neurogenesis
Description	Neural stem cells (NSCs) in the adult mammalian subependymal zone maintain a glial identity and the developmental potential to generate neurons during the lifetime. Production of neurons from these NSCs is not direct but follows an orderly pattern of cell progression which allows the gradual increase along the neurogenic lineage in the expression of pro-neural factors needed for neuronal specification. In this context, tightly regulated translation of existing transcriptional programs represents a potential mechanism to avoid the critical challenge posed by genes that encode proteins with conflicting functions, i.e. self-renew or differentiate. Here, we identify RNA-binding protein MEX3A as a post-transcriptional regulator of a set of stemness-associated transcripts at critical transitions in the subependymal neurogenic lineage. MEX3A binding to a set of quiescence-related RNAs in activated NSCs is needed for their return to quiescence, playing a role in the long-term maintenance of the NSC pool. Furthermore, it is required for the repression of the same program at the onset of neuronal differentiation. Our data indicate that MEX3A is a pivotal regulator of adult mammalian neurogenesis acting as a translational remodeller.
HostingRepository	PRIDE
AnnounceDate	2023-01-08
AnnouncementXML	Submission_2023-01-08_11:03:30.806.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	LuzValero
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-20 20:02:23	ID requested
⏵ 1	2023-01-08 11:03:31	announced

Dataset with its publication pending

submitter keyword: mammalian neurogenesis,MEX3A, neuronal differentiation, post-transcriptional regulator

IsabelFariñas
contact affiliation	Departamento de Biología Celular, Biología Funcional y Antropología Física,Instituto de Biotecnología y Biomedicina
contact email	isabel.farinas@uv.es
lab head
LuzValero
contact affiliation	Universitat de Valencia
contact email	mluz.valero@uv.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD038983

PRIDE project URI

• PRIDE
  1. PXD038983
     1. Label: PRIDE project
     2. Name: Post-transcriptional control of a stemness signature by RNA-binding 8 protein MEX3A regulates adult neurogenesis