PXD038982

PXD038982 is an original dataset announced via ProteomeXchange.

Title	Proteomics and Metabolomics based analysis of Metabolic changes in a swine model of Pulmonary Hypertension
Description	Pulmonary vein stenosis (PVS) is a rare type of Pulmonary Hypertension (PH), which impacts the flow and pressure within the lung tissue and vasculature resulting in endothelial dysfunction and metabolic changes. We used a pig model in order to mimic PH post PVS using pulmonary vein banding (PVB) of the lower lobes for 12 weeks to investigate the alteration of pressure and flow which provides an impetus for development of PH. In order to develop site-specific therapies, our current study aimed to employ proteomics and metabolomics on both the upper and lower lobes of the pig lung to identify compartment-specific metabolic alterations.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:45:06.059.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bachuki Shashikadze
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-20 20:02:07	ID requested
1	2023-04-20 04:19:54	announced
⏵ 2	2023-11-14 08:45:12	announced	2023-11-14: Updated project metadata.

Sen P, Shashikadze B, Flenkenthaler F, Van de Kamp E, Tian S, Meng C, Gigl M, Fr, ö, hlich T, Merkus D, Proteomics- and Metabolomics-Based Analysis of Metabolic Changes in a Swine Model of Pulmonary Hypertension. Int J Mol Sci, 24(5):(2023) [pubmed]

submitter keyword: proteomics, metabolomics, pulmonary hypertension, pig model

Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Germnay
contact email	Frohlich@genzentrum.lmu.de
lab head
Bachuki Shashikadze
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	shashikadze@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD038982

PRIDE project URI

• PRIDE
  1. PXD038982
     1. Label: PRIDE project
     2. Name: Proteomics and Metabolomics based analysis of Metabolic changes in a swine model of Pulmonary Hypertension