PXD038919

PXD038919 is an original dataset announced via ProteomeXchange.

Title	Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii
Description	Toxoplasma gondii (T. gondii) is an opportunistic parasite that can infect the central nervous system, causing severe toxoplasmosis and behavioral cognitive impairment. Mortality is high in immunocompromised individuals with toxoplasmosis, most commonly due to reactivation of infection in the central nervous system (CNS). There are still no effective vaccines and drugs for the prevention and treatment of toxoplasmosis. There are five developmental stages for T. gondii to complete life cycle, of which the tachyzoite and bradyzoite stages are the key to the acute and chronic infection. In this study, to better understanding of how T. gondii interacts with the host central nervous system at different stages of infection, we constructed acute and chronic infection models of T. gondii in astrocytes, and used lab-free proteomics to detect the proteome changes before and after infection, respectively.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:13:28.808.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huanhuan Xie
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-19 03:29:29	ID requested
1	2023-08-24 18:50:01	announced
⏵ 2	2023-11-14 07:13:29	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Toxoplasma gondii

acute and chronic infection

toxoplasmosis

astrocytes

Label-free proteomics

differentially expressed protein

Kun Yin
contact affiliation	Shandong Institute of Parasitic Diseases, Shandong First Medical University, No. 11 Taibai Middle Road, Jining, 272033, China.
contact email	1312830035@qq.com
lab head
Huanhuan Xie
contact affiliation	Shandong Institute of Parasitic Diseases
contact email	1312830035@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/08/PXD038919

PRIDE project URI

• PRIDE
  1. PXD038919
     1. Label: PRIDE project
     2. Name: Label-free quantitative proteomic analyses of mouse astrocytes provides insight into the host response mechanism at different developmental stages of Toxoplasma gondii