PXD038875
PXD038875 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeted quantitative proteomics of Plasma in Patients with Acute Myocardial Infarction |
| Description | Early identification and treatment of Sudden Cardiac Death (SCD) post-myocardial infarction (MI) are currently limited by unclear warning indicators and elusive pathogenesis. Here, we constructed a comprehensive multi-omics blood atlas in the acute phase of AMI from 55 pairs of SCD patients and matched survivors, confirmed immune dysregulation and metabolic disorders as the biological hubs leading to post-MI SCD. Targeted proteome quantification identified a TOP4 protein-based biomarker panel, which were validated by internal and external cohorts, and confirmed a superior early prediction power of SCD to traditional clinical risk models. Further interventions targeting complement factor D (CFD) suggested a potential therapeutic strategy for high-risk MI. Our study provided valuable knowledge about the molecular changes and pathogenesis of SCD, shed light on accurate risk stratification and potential therapeutic targets in high SCD-risk MI. |
| HostingRepository | iProX |
| AnnounceDate | 2022-12-17 |
| AnnouncementXML | Submission_2025-05-15_18:37:09.042.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yafei Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-12-17 20:22:30 | ID requested | |
| ⏵ 1 | 2025-05-15 18:37:09 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Targeted quantitative proteomics, PRM, SCD post AMI |
Contact List
| Maomao Zhang | |
|---|---|
| contact affiliation | The Second Affiliated Hospital of Harbin Medical University |
| contact email | maomaolp1983@163.com |
| lab head | |
| Yafei Zhang | |
| contact affiliation | The Second Affiliated Hospital of Harbin Medical University |
| contact email | yafei19990511@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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