PXD038874

PXD038874 is an original dataset announced via ProteomeXchange.

Title	Sulconazole induces PANoptosis to increase radiosensitivity of esophageal cancer by triggering oxidative stress and inhibiting glycolysis
Description	Esophageal cancer is the seventh most common cancer in the world. Although traditional treatment methods such as radiotherapy and chemotherapy have good effects, their side effects and drug resistance are still obvious. The repositioning of drug function provides new ideas for the research and development of anticancer drugs. We previously identified a Food and Drug Administration (FDA) approved drugsulconazole can effectively inhibit the growth of esophageal cancer cells, but its molecular mechanism is not clear. Here, our study demonstrated that sulconazole had a broad spectrum of anticancer effects. It can not only inhibit the proliferation, but also inhibit the migration of esophageal cancer cells. Both transcriptomic sequencing and proteomic sequencing showed that sulconazole could promote various programmed cell death and inhibited glycolysis and its related signal pathways. Experimentally, wefound that sulconazole induced apoptosis, pyroptosis and ferroptosis. Mechanistically, sulconazole triggered mitochondrial oxidative stress, inhibited glycolysis and activating BCL2/Bax/Caspase3 axis. Finally, we discovered that low-dose sulconazole canincrease radiosensitivity of esophageal cancer cells. Taken together, these new findings provided strong laboratory evidence for the clinical application of sulconazole in esophageal cancer.
HostingRepository	iProX
AnnounceDate	2022-12-17
AnnouncementXML	Submission_2024-02-03_20:34:55.183.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liyan Xu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	TMT6plex reporter fragment
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-17 20:06:08	ID requested
1	2022-12-17 20:06:31	announced
⏵ 2	2024-02-03 20:34:55	announced	2024-02-04: Update publication information.

Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY, Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer. Mol Cell Proteomics, 22(6):100551(2023) [pubmed]

submitter keyword: Sulconazole,PANoptosis,oxidative stress

Liyan Xu
contact affiliation	Institute of Oncologic Pathology, Shantou University Medical College
contact email	lyxu@stu.edu.cn
lab head
Liyan Xu
contact affiliation	Institute of Oncologic Pathology, Shantou University Medical College
contact email	lyxu@stu.edu.cn
dataset submitter

iProX dataset URI