PXD038850

PXD038850 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PRODUCT CHARACTERIZATION AND PRECLINICAL SAFETY OF UMBILICAL CORD MESENCHYMAL STROMAL CELL-DERIVED SMALL EXTRACELLULAR VESICLES
Description	Mesenchymal stromal cells (MSCs) are multipotent progenitors that can be isolated from different sources, such as the bone marrow, adipose tissue and umbilical cord. The therapeutic potential of MSCs is related to a plethora of immunomodulatory, anti-inflammatory and pro-repair actions, which are at least partially dependent on their secretome. Among the components of MSCs' secretome, EVs have received considerable attention because MSC-EVs exert similar therapeutic properties as their parent cells. Among the different MSC sources for EV production, human umbilical cord MSCs (hUCMSCs) show advantages such as tissue availability, high proliferative profile of the cells and potential beneficial therapeutic effects in a variety of different diseases, such as stroke This study aimed to provide novel insights for future hUCMSC-EVs research and treatment selection. We investigated the influence of the culture and harvesting conditions on the EV proteomic profile, productivity, surface markers expression and evaluated their in vivo biodistribution and toxicity.
HostingRepository	PRIDE
AnnounceDate	2024-05-04
AnnouncementXML	Submission_2024-05-04_08:10:43.475.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gisele Rocha
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap XL ETD

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-14 22:07:09	ID requested
⏵ 1	2024-05-04 08:10:44	announced

Publication List

10.1016/J.JCYT.2024.04.074;

10.1016/J.JCYT.2024.04.074;

Keyword List

submitter keyword: mesenchymal stromal cells
extracellular vesicles
proteomics
preclinical
biodistribution

submitter keyword: mesenchymal stromal cells

extracellular vesicles

proteomics

preclinical

biodistribution

Contact List

Bruno Solano de Freitas Souza
contact affiliation	Gonçalo Moniz Institute, FIOCRUZ, Salvador, Brazil D'Or Institute for Research and Education (IDOR), Salvador, Brazil Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil
contact email	bruno.solano@fiocruz.br
lab head
Gisele Rocha
contact affiliation	D'Or Institute for Research and Education (IDOR) Gonçalo Moniz Institute, FIOCRUZ
contact email	givieiraroch@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD038850
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/05/PXD038850

PRIDE project URI

Repository Record List

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