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PXD038840

PXD038840 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImmunization with a heat-killed Prm1 deletion strain protects the host from Cryptococcus neoformans infection
DescriptionSystemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen found throughout the world, frequently results in lethal cryptococcal pneumonia and meningoencephalitis, and no effective treatments of cryptococcosis are available. Here, we describe Prm1, a novel regulator of virulence in C. neoformans. C. neoformans prm1 cells exhibit extreme sensitivity to various environmental stress conditions. Furthermore, prm1 cells show deficiencies in the biosynthesis of chitin, chitosan, and mannoprotein, which in turn result in impairment of cell wall integrity. Treatment of mice with heat-killed prm1 cells was found to facilitate the host immunological defence against infection with wild-type C. neoformans. Further investigation demonstrated that prm1 cells strongly promote pulmonary production of interferon- and Th1 responses, leading to activation of macrophage M1 differentiation and inhibition of M2 polarization. Therefore, our findings suggest that C. neoformans Prm1 may be a viable target for the development of anti-cryptococcosis medications and, cells lacking Prm1 represent a promising candidate for a vaccine.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:05:33.668.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitter超 李
SpeciesList scientific name: Cryptococcus neoformans AD hybrid; NCBI TaxID: 192011;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-14 21:55:05ID requested
12023-10-11 02:24:19announced
22023-11-14 08:29:54announced2023-11-14: Updated project metadata.
32024-10-22 06:05:34announced2024-10-22: Updated project metadata.
Publication List
10.1080/22221751.2023.2244087;
Keyword List
submitter keyword: Cryptococcus neoformans
MMP
cell wall
fungal vaccine
IFN-γ
macrophage polarization
drug targets.
Contact List
Chao li
contact affiliationCollege of Life and Health Sciences, Northeastern University
contact emailfMssop_li@163.com
lab head
超 李
contact affiliationCollege of Life and Health Sciences, Northeastern University
contact emailfMssop_li@163.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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