PXD038840 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Immunization with a heat-killed Prm1 deletion strain protects the host from Cryptococcus neoformans infection |
Description | Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen found throughout the world, frequently results in lethal cryptococcal pneumonia and meningoencephalitis, and no effective treatments of cryptococcosis are available. Here, we describe Prm1, a novel regulator of virulence in C. neoformans. C. neoformans prm1 cells exhibit extreme sensitivity to various environmental stress conditions. Furthermore, prm1 cells show deficiencies in the biosynthesis of chitin, chitosan, and mannoprotein, which in turn result in impairment of cell wall integrity. Treatment of mice with heat-killed prm1 cells was found to facilitate the host immunological defence against infection with wild-type C. neoformans. Further investigation demonstrated that prm1 cells strongly promote pulmonary production of interferon- and Th1 responses, leading to activation of macrophage M1 differentiation and inhibition of M2 polarization. Therefore, our findings suggest that C. neoformans Prm1 may be a viable target for the development of anti-cryptococcosis medications and, cells lacking Prm1 represent a promising candidate for a vaccine. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:05:33.668.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | 超 李 |
SpeciesList | scientific name: Cryptococcus neoformans AD hybrid; NCBI TaxID: 192011; |
ModificationList | No PTMs are included in the dataset |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-14 21:55:05 | ID requested | |
1 | 2023-10-11 02:24:19 | announced | |
2 | 2023-11-14 08:29:54 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 06:05:34 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Cryptococcus neoformans |
MMP |
cell wall |
fungal vaccine |
IFN-γ |
macrophage polarization |
drug targets. |
Contact List
Chao li |
contact affiliation | College of Life and Health Sciences, Northeastern University |
contact email | fMssop_li@163.com |
lab head | |
超 李 |
contact affiliation | College of Life and Health Sciences, Northeastern University |
contact email | fMssop_li@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038840
- Label: PRIDE project
- Name: Immunization with a heat-killed Prm1 deletion strain protects the host from Cryptococcus neoformans infection