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PXD038811

PXD038811 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFOX transcription factors are common regulators of Wnt/β-catenin signaling
DescriptionThe Wnt/β-catenin signaling pathway is a critical regulator of development and stem cell maintenance. Mounting evidence suggests that the context-specific outcome of Wnt signaling is determined by the collaborative action of multiple transcription factors, including members of the highly conserved forkhead box (FOX) protein family. The contribution of FOX transcription factors to Wnt signaling has not been investigated in a systemic manner. Here, by combining β-catenin reporter assays with Wnt pathway-focused qPCR arrays and proximity proteomics of selected FOX family members, we determine that most FOX proteins are involved in the regulation of Wnt pathway activity and the expression of Wnt ligands and target genes. We conclude that FOX proteins are common regulators of the Wnt/β-catenin pathway that may control the outcome of Wnt signaling in a tissue-specific manner.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_06:47:27.189.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD038811
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterLavanya Moparthi
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-13 22:57:46ID requested
12023-04-19 12:23:45announced
22023-11-14 06:47:28announced2023-11-14: Updated project metadata.
Publication List
10.6019/PXD038811;
Moparthi L, Koch S, -catenin-dependent gene transcription. J Biol Chem, 299(5):104667(2023) [pubmed]
Keyword List
submitter keyword: FOX transcription factors, TurboID, Wnt signaling, LC-MS/MS
Contact List
Stefan Koch
contact affiliationDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden.
contact emailstefan.koch@liu.se
lab head
Lavanya Moparthi
contact affiliationLINKÖPING UNIVERSITY
contact emaillavanya.moparthi@liu.se
dataset submitter
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Dataset FTP location
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PRIDE project URI
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