PXD038811 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | FOX transcription factors are common regulators of Wnt/β-catenin signaling |
Description | The Wnt/β-catenin signaling pathway is a critical regulator of development and stem cell maintenance. Mounting evidence suggests that the context-specific outcome of Wnt signaling is determined by the collaborative action of multiple transcription factors, including members of the highly conserved forkhead box (FOX) protein family. The contribution of FOX transcription factors to Wnt signaling has not been investigated in a systemic manner. Here, by combining β-catenin reporter assays with Wnt pathway-focused qPCR arrays and proximity proteomics of selected FOX family members, we determine that most FOX proteins are involved in the regulation of Wnt pathway activity and the expression of Wnt ligands and target genes. We conclude that FOX proteins are common regulators of the Wnt/β-catenin pathway that may control the outcome of Wnt signaling in a tissue-specific manner. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_06:47:27.189.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD038811 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Lavanya Moparthi |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-13 22:57:46 | ID requested | |
1 | 2023-04-19 12:23:45 | announced | |
⏵ 2 | 2023-11-14 06:47:28 | announced | 2023-11-14: Updated project metadata. |
Publication List
10.6019/PXD038811; |
Moparthi L, Koch S, -catenin-dependent gene transcription. J Biol Chem, 299(5):104667(2023) [pubmed] |
Keyword List
submitter keyword: FOX transcription factors, TurboID, Wnt signaling, LC-MS/MS |
Contact List
Stefan Koch |
contact affiliation | Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden. |
contact email | stefan.koch@liu.se |
lab head | |
Lavanya Moparthi |
contact affiliation | LINKÖPING UNIVERSITY |
contact email | lavanya.moparthi@liu.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038811
- Label: PRIDE project
- Name: FOX transcription factors are common regulators of Wnt/β-catenin signaling