PXD038811

PXD038811 is an original dataset announced via ProteomeXchange.

Title	FOX transcription factors are common regulators of Wnt/β-catenin signaling
Description	The Wnt/β-catenin signaling pathway is a critical regulator of development and stem cell maintenance. Mounting evidence suggests that the context-specific outcome of Wnt signaling is determined by the collaborative action of multiple transcription factors, including members of the highly conserved forkhead box (FOX) protein family. The contribution of FOX transcription factors to Wnt signaling has not been investigated in a systemic manner. Here, by combining β-catenin reporter assays with Wnt pathway-focused qPCR arrays and proximity proteomics of selected FOX family members, we determine that most FOX proteins are involved in the regulation of Wnt pathway activity and the expression of Wnt ligands and target genes. We conclude that FOX proteins are common regulators of the Wnt/β-catenin pathway that may control the outcome of Wnt signaling in a tissue-specific manner.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_06:47:27.189.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD038811
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lavanya Moparthi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-13 22:57:46	ID requested
1	2023-04-19 12:23:45	announced
⏵ 2	2023-11-14 06:47:28	announced	2023-11-14: Updated project metadata.

10.6019/PXD038811;

Moparthi L, Koch S, -catenin-dependent gene transcription. J Biol Chem, 299(5):104667(2023) [pubmed]

submitter keyword: FOX transcription factors, TurboID, Wnt signaling, LC-MS/MS

Stefan Koch
contact affiliation	Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden.
contact email	stefan.koch@liu.se
lab head
Lavanya Moparthi
contact affiliation	LINKÖPING UNIVERSITY
contact email	lavanya.moparthi@liu.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD038811

PRIDE project URI

• PRIDE
  1. PXD038811
     1. Label: PRIDE project
     2. Name: FOX transcription factors are common regulators of Wnt/β-catenin signaling