<<< Full experiment listing

PXD038787

PXD038787 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCSF glycoproteomics reveals brain-specific changes in glyco-sylation in congenital disorders of glycosylation
DescriptionIn this project, CSF samples from healthy volunteers and patients diagnosed with congenital disorders of glycosylation (CDG) were analyzed with MS-based glycoproteomics to characterize the glycoproteome in the two cohorts. In order to identify highly truncated glycopeptides and glycopeptides that show the complete loss of glycosylation, we chose to not perform a glycopeptide enrichment. Using the high identification rate of the timsTOF Pro including PASEF fragmentation, we were able to detect over 800 unique glycopeptides. We show that changes in protein N-glycosylation of CDG patients can be different on brain-derived proteins compared to blood derived proteins.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:59:59.780.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMelissa Baerenfaenger
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-12 23:07:40ID requested
12023-01-18 14:31:06announced
22023-11-14 09:00:00announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Glycoproteomics, Brain-type glycosylation, CSF
Contact List
Melissa Baerenfaenger
contact affiliationVU Amsterdam, Division of BioAnalytical Chemistry
contact emailj.m.baerenfaenger@vu.nl
lab head
Melissa Baerenfaenger
contact affiliationVU Amsterdam, Division of BioAnalytical Chemistry
contact emailj.m.baerenfaenger@vu.nl
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD038787
PRIDE project URI
Repository Record List
[ + ]