PXD038787 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | CSF glycoproteomics reveals brain-specific changes in glyco-sylation in congenital disorders of glycosylation |
Description | In this project, CSF samples from healthy volunteers and patients diagnosed with congenital disorders of glycosylation (CDG) were analyzed with MS-based glycoproteomics to characterize the glycoproteome in the two cohorts. In order to identify highly truncated glycopeptides and glycopeptides that show the complete loss of glycosylation, we chose to not perform a glycopeptide enrichment. Using the high identification rate of the timsTOF Pro including PASEF fragmentation, we were able to detect over 800 unique glycopeptides. We show that changes in protein N-glycosylation of CDG patients can be different on brain-derived proteins compared to blood derived proteins. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:59:59.780.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Melissa Baerenfaenger |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-12 23:07:40 | ID requested | |
1 | 2023-01-18 14:31:06 | announced | |
⏵ 2 | 2023-11-14 09:00:00 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Glycoproteomics, Brain-type glycosylation, CSF |
Contact List
Melissa Baerenfaenger |
contact affiliation | VU Amsterdam, Division of BioAnalytical Chemistry |
contact email | j.m.baerenfaenger@vu.nl |
lab head | |
Melissa Baerenfaenger |
contact affiliation | VU Amsterdam, Division of BioAnalytical Chemistry |
contact email | j.m.baerenfaenger@vu.nl |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/01/PXD038787 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038787
- Label: PRIDE project
- Name: CSF glycoproteomics reveals brain-specific changes in glyco-sylation in congenital disorders of glycosylation