PXD038733

PXD038733 is an original dataset announced via ProteomeXchange.

Title	A Multigroup Study of Plasma in Patients with Acute Myocardial Infarction.
Description	Early identification and treatment of Sudden Cardiac Death (SCD) post-myocardial infarction (MI) are currently limited by unclear warning indicators and elusive pathogenesis. Here, we constructed a comprehensive multi-omics blood atlas in the acute phase of AMI from 55 pairs of SCD patients and matched survivors, confirmed immune dysregulation and metabolic disorders as the biological hubs leading to post-MI SCD. Targeted proteome quantification identified a TOP4 protein-based biomarker panel, which were validated by internal and external cohorts, and confirmed a superior early prediction power of SCD to traditional clinical risk models. Further interventions targeting complement factor D (CFD) suggested a potential therapeutic strategy for high-risk MI. Our study provided valuable knowledge about the molecular changes and pathogenesis of SCD, shed light on accurate risk stratification and potential therapeutic targets in high SCD-risk MI.
HostingRepository	iProX
AnnounceDate	2022-12-09
AnnouncementXML	Submission_2025-05-15_18:36:47.232.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maomao Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ACQUITY UPLC I-Class; Agilent instrument model; Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-11 19:35:29	ID requested
⏵ 1	2025-05-15 18:36:47	announced

Dataset with its publication pending

submitter keyword: multi-omics, SCD post-AMI, biomarker, proteomic, metabolomic, transcriptome

Maomao Zhang
contact affiliation	The Second Affiliated Hospital of Harbin Medical University
contact email	maomaolp1983@163.com
lab head
Maomao Zhang
contact affiliation	The Second Affiliated Hospital of Harbin Medical University
contact email	yafei19990511@163.com
dataset submitter

iProX dataset URI