PXD038731

PXD038731 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance
Description	Affinity-purification coupled to mass spectrometry of GFP-ZNF432 expressed in wild-type and PARP1 KO 293T cells (with and without H2O2-induced DNA damage and PARP1 activation).
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_07:05:16.191.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jean-Philippe Gagne
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue; acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-10 14:55:54	ID requested
⏵ 1	2024-01-26 07:05:17	announced

Publication List

O'Sullivan J, Kothari C, Caron MC, Gagn, é JP, Jin Z, Nonfoux L, Beneyton A, Coulombe Y, Thomas M, Atalay N, Meng XW, Milano L, Jean D, Boisvert FM, Kaufmann SH, Hendzel MJ, Masson JY, Poirier GG, ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance. Nucleic Acids Res, 51(20):11056-11079(2023) [pubmed]
10.1093/nar/gkad791;

O'Sullivan J, Kothari C, Caron MC, Gagn, é JP, Jin Z, Nonfoux L, Beneyton A, Coulombe Y, Thomas M, Atalay N, Meng XW, Milano L, Jean D, Boisvert FM, Kaufmann SH, Hendzel MJ, Masson JY, Poirier GG, ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance. Nucleic Acids Res, 51(20):11056-11079(2023) [pubmed]

10.1093/nar/gkad791;

Keyword List

submitter keyword: PARP1, DNA repair, PARP inhibitors, homologous recombination,ZNF432

submitter keyword: PARP1, DNA repair, PARP inhibitors, homologous recombination,ZNF432

Contact List

Guy G Poirier
contact affiliation	Centre de recherche du CHU de Québec - Université Laval
contact email	guy.poirier@crchudequebec.ulaval.ca
lab head
Jean-Philippe Gagne
contact affiliation	Laval University Medical Research Center
contact email	jean-philippe.gagne@crchudequebec.ulaval.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD038731
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD038731

PRIDE project URI

Repository Record List

[ + ]