PXD038726 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Title: Non-canonical functions of SNAIL drive context-specific progression |
Description | SNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a master regulator of epithelial-to-mesenchymal transition (EMT). Here, we report EMT-independent oncogenic SNAIL functions in cancer. Using genetic models, we systematically interrogated SNAIL effects in various oncogenic backgrounds and tissue types. SNAIL related phenotypes displayed remarkable tissue- and genetic context-dependencies, ranging from protective effects as observed in KRAS- or WNT-driven intestinal cancers, to dramatic acceleration of tumorigenesis, as shown in KRAS-induced pancreatic cancer. Unexpectedly, SNAIL-driven oncogenesis was not associated with E-cadherin downregulation or induction of an overt EMT program. Instead, we show that SNAIL induces bypass of senescence and cell cycle progression through p16INK4A-independent inactivation of the Retinoblastoma (RB)-restriction checkpoint. Collectively, our work identifies novel non-canonical EMT-independent functions of SNAIL and unravel its complex context-dependent role in cancer. |
HostingRepository | PRIDE |
AnnounceDate | 2022-12-13 |
AnnouncementXML | Submission_2022-12-13_00:33:41.825.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | TanjaBange |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-10 14:51:06 | ID requested | |
⏵ 1 | 2022-12-13 00:33:42 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: transcription, EMT, tissue specificity, SNAIL, cell cycle,: Cancer, ChIP-MS |
Contact List
Maria S.Robles |
contact affiliation | Institute of Medical Psychology LMU Munich Goethestrasse 31 80336 Munich |
contact email | charo.robles@med.uni-muenchen.de |
lab head | |
TanjaBange |
contact affiliation | LMU Munich |
contact email | tanja.bange@med.uni-muenchen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD038726 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038726
- Label: PRIDE project
- Name: Title: Non-canonical functions of SNAIL drive context-specific progression