⮝ Full datasets listing

PXD038726

PXD038726 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTitle: Non-canonical functions of SNAIL drive context-specific progression
DescriptionSNAIL is a key transcriptional regulator in embryonic development and cancer. Its effects in physiology and disease are believed to be linked to its role as a master regulator of epithelial-to-mesenchymal transition (EMT). Here, we report EMT-independent oncogenic SNAIL functions in cancer. Using genetic models, we systematically interrogated SNAIL effects in various oncogenic backgrounds and tissue types. SNAIL related phenotypes displayed remarkable tissue- and genetic context-dependencies, ranging from protective effects as observed in KRAS- or WNT-driven intestinal cancers, to dramatic acceleration of tumorigenesis, as shown in KRAS-induced pancreatic cancer. Unexpectedly, SNAIL-driven oncogenesis was not associated with E-cadherin downregulation or induction of an overt EMT program. Instead, we show that SNAIL induces bypass of senescence and cell cycle progression through p16INK4A-independent inactivation of the Retinoblastoma (RB)-restriction checkpoint. Collectively, our work identifies novel non-canonical EMT-independent functions of SNAIL and unravel its complex context-dependent role in cancer.
HostingRepositoryPRIDE
AnnounceDate2022-12-13
AnnouncementXMLSubmission_2022-12-13_00:33:41.825.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTanjaBange
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-10 14:51:06ID requested
12022-12-13 00:33:42announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: transcription, EMT, tissue specificity, SNAIL, cell cycle,: Cancer, ChIP-MS
Contact List
Maria S.Robles
contact affiliationInstitute of Medical Psychology LMU Munich Goethestrasse 31 80336 Munich
contact emailcharo.robles@med.uni-muenchen.de
lab head
TanjaBange
contact affiliationLMU Munich
contact emailtanja.bange@med.uni-muenchen.de
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD038726
PRIDE project URI
Repository Record List
[ + ]