PXD038711

PXD038711 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of the intracellular protein targets of a clickable half-sandwich iridium complex by chemical proteomics
Description	This study aims at identifying intracellular proteins that are targeted by half-sandwich Ir(III) organometallic drugs. We recently demonstrated that half-sandwich Ir(III) complexes are able to form adducts with the side chain of certain amino-acids (Cys and His for example) and with cellular proteins in vivo. We use an azido-substituted half-sandwich iridium complex to fish out protein adducts, using click chemistry and ethynyl-agarose beads
HostingRepository	PRIDE
AnnounceDate	2024-04-11
AnnouncementXML	Submission_2024-04-11_03:44:58.641.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vanessa Masson
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-09 03:29:15	ID requested
⏵ 1	2024-04-11 03:44:59	announced

Publication List

10.1021/ACS.JMEDCHEM.3C02000;

10.1021/ACS.JMEDCHEM.3C02000;

Keyword List

submitter keyword: Anticancer drugs, Target profiling, HEK293

submitter keyword: Anticancer drugs, Target profiling, HEK293

Contact List

Damarys Loew
contact affiliation	Head of the Curie Institute Mass Spectrometry Platform
contact email	damarys.loew@curie.fr
lab head
Vanessa Masson
contact affiliation	Institut Curie - Centre de Recherche
contact email	vanessa.masson@curie.fr
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD038711
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD038711

PRIDE project URI

Repository Record List

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