PXD038693

PXD038693 is an original dataset announced via ProteomeXchange.

Title	The central nervous system’s proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2
Description	During severe systemic infections with and without sepsis neurological changes are common and range from sickness behavior to septic associated encephalopathy. Encephalopathy is due to a system-wide inflammatory response leading to an often fatal increase in the permeability of the blood-brain barrier. To elucidate the cytotoxic impact and brain-specific host response during coronavirus disease 2019 (COVID-19), we profiled the olfactory mucosa, olfactory bulb, brainstem and cerebellum from deceased COVID-19 patients who underwent rapid autopsy.
HostingRepository	PRIDE
AnnounceDate	2023-11-06
AnnouncementXML	Submission_2023-11-06_14:42:40.570.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MichaelMülleder
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-08 16:23:11	ID requested
⏵ 1	2023-11-06 14:42:40	announced

Dataset with its publication pending

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: COVID-19, encephalopathy

HelenaRadbruch
contact affiliation	Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117 Berlin, Germany
contact email	helena.radbruch@charite.de
lab head
MichaelMülleder
contact affiliation	Core Facility -High-Throughput Mass Spectrometry, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health (BIH), Berlin, Germany
contact email	michael.muelleder@charite.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/11/PXD038693

PRIDE project URI

• PRIDE
  1. PXD038693
     1. Label: PRIDE project
     2. Name: The central nervous system’s proteogenomic and spatial imprint upon systemic viral infection, like SARS-CoV-2