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PXD038663

PXD038663 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLC-MSMS of the MHC-I immunopeptidome of AML cell lines
DescriptionThe hypomethylating agent 5-azacytidine (AZA) is the first-line induction therapy for AML patients unsuitable for intensive chemotherapy. The anti-tumor effect of AZA results in part from T-cell cytotoxic responses against MHC-I-associated peptides (MAPs) deriving from hypermethylated genomic regions such as cancer-testis antigens (CTAs), or endogenous retroelements (EREs). However, clear evidence supporting higher ERE MAPs presentation after AZA treatment in AML is lacking. Therefore, we examined the immunopeptidome of four AML cell lines treated with AZA through a proteogenomic approach to validate this hypothesis.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_06:36:25.833.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD038663
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterCourcelles Mathieu
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-07 12:22:20ID requested
12024-04-17 06:14:28announced
22024-10-22 06:36:26announced2024-10-22: Updated project metadata.
Publication List
10.1038/S41375-024-02250-6;
10.6019/PXD038663;
Keyword List
submitter keyword: acute myeloid leukemia, EREs,5-azacitidine, immunopeptidome, MHC-I
Contact List
Pierre Thibault
contact affiliationInstitute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4
contact emailpierre.thibault@umontreal.ca
lab head
Courcelles Mathieu
contact affiliationIRIC
contact emailmathieu.courcelles@umontreal.ca
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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