PXD038663 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | LC-MSMS of the MHC-I immunopeptidome of AML cell lines |
Description | The hypomethylating agent 5-azacytidine (AZA) is the first-line induction therapy for AML patients unsuitable for intensive chemotherapy. The anti-tumor effect of AZA results in part from T-cell cytotoxic responses against MHC-I-associated peptides (MAPs) deriving from hypermethylated genomic regions such as cancer-testis antigens (CTAs), or endogenous retroelements (EREs). However, clear evidence supporting higher ERE MAPs presentation after AZA treatment in AML is lacking. Therefore, we examined the immunopeptidome of four AML cell lines treated with AZA through a proteogenomic approach to validate this hypothesis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:36:25.833.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD038663 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Courcelles Mathieu |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deamidated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-07 12:22:20 | ID requested | |
1 | 2024-04-17 06:14:28 | announced | |
⏵ 2 | 2024-10-22 06:36:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: acute myeloid leukemia, EREs,5-azacitidine, immunopeptidome, MHC-I |
Contact List
Pierre Thibault |
contact affiliation | Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 |
contact email | pierre.thibault@umontreal.ca |
lab head | |
Courcelles Mathieu |
contact affiliation | IRIC |
contact email | mathieu.courcelles@umontreal.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/04/PXD038663 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038663
- Label: PRIDE project
- Name: LC-MSMS of the MHC-I immunopeptidome of AML cell lines