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PXD038643

PXD038643 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFIRE mimics a 14-3-3-binding motif to promote Phytophthora palmivora infection
DescriptionThe oomycete Phytophthora palmivora infects a wide range of tropical crops worldwide. Like other filamentous plant pathogens, it secretes effectors to colonise plant tissues. Here we characterise FIRE, an RXLR effector that contains a canonical mode I 14-3-3 phospho-sensor binding motif that is conserved in effectors of several Phytophthora species. FIRE is phosphorylated in planta and interacts with multiple 14-3-3 proteins. Binding is sensitive to the R18 14-3-3 inhibitor. FIRE promotes plant susceptibility and co-localises with its target around haustoria. This work uncovers a new type of oomycete effector target mechanism. It demonstrates that substrate mimicry for 14-3-3 proteins is a cross-kingdom effector strategy used by both prokaryotic and eukaryotic plant pathogens to suppress host immunity.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_07:00:08.769.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD038643
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterEdouard Evangelisti
SpeciesList scientific name: Nicotiana benthamiana; NCBI TaxID: 4100;
ModificationListphosphorylated residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-07 07:59:54ID requested
12024-10-01 01:25:12announced
22024-10-22 07:00:09announced2024-10-22: Updated project metadata.
Publication List
10.1094/MPMI-12-22-0251-R;
10.6019/PXD038643;
Keyword List
submitter keyword: biotrophy, effector, phosphorylation,Phytophthora, susceptibility
Contact List
Sebastian Schornack
contact affiliationSainsbury Laboratory Cambridge University (SLCU)
contact emailsebastian.schornack@slcu.cam.ac.uk
lab head
Edouard Evangelisti
contact affiliationWageningen University & Research
contact emailedouard.evangelisti@wur.nl
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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