PXD038638

PXD038638 is an original dataset announced via ProteomeXchange.

Title	MS-based phosphoproteomic of cytarabine-treated FLT3-ITD cells
Description	ITD mutations in the FLT3 gene occur in the 30% of acute myeloid leukemia patients. The integration of ITD in the tyrosine kinase domain (TKD-ITD) of the FLT3 receptor has been shown to confer resistance to standard chemotherapy treatment. We applied state-of-the-art, high-sensitive, mass spectrometry (MS)-based (phospho)proteomics to investigate the molecular mechanisms underlying the sensitivity to cytarabine therapy in FLT3-ITD cells.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:03:20.180.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Francesca Sacco
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-07 07:19:13	ID requested
1	2023-07-20 11:30:58	announced
⏵ 2	2023-11-14 09:03:28	announced	2023-11-14: Updated project metadata.

Pugliese GM, Venafra V, Bica V, Massacci G, Latini S, Graziosi S, Fischer T, Mougiakakos D, Boettcher M, Perfetto L, Sacco F, Impact of FLT3-ITD location on cytarabine sensitivity in AML: a network-based approach. Leukemia, 37(5):1151-1155(2023) [pubmed]

submitter keyword: MS-based phosphoproteomic,AML resistance, chemotherapy

Francesca Sacco
contact affiliation	Department of Biology, University of Rome Tor Vergata, Via delle Ricerca Scientifica 1, 00133 Rome, Italy
contact email	francesca.sacco@uniroma2.it
lab head
Francesca Sacco
contact affiliation	University of Rome Tor Vergata
contact email	francesca.sacco@uniroma2.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD038638

PRIDE project URI

• PRIDE
  1. PXD038638
     1. Label: PRIDE project
     2. Name: MS-based phosphoproteomic of cytarabine-treated FLT3-ITD cells