PXD038584

PXD038584 is an original dataset announced via ProteomeXchange.

Title	Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis
Description	Mast cells are phenotypically and functionally highly heterogeneous, and their state is possibly controlled by their local microenvironment. Therefore, concrete analyses are needed to understand whether mast cells act as powerful motivators or dispensable bystanders in specific diseases. Here, we evaluated the correlation between synovial mast cells and rheumatoid arthritis (RA) disease severity, and the efficacy of therapeutic interventions against mast cells. We showed that degranulation of mast cells in inflammatory synovial tissues of RA patients was induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), and the expression of MHC class II (MHC II) and costimulatory molecules on mast cells were upregulated. These unique signaling response led to mast cell activation and promoted T cell responses, resulting in the progression of RA. Collagen-induced arthritis mouse models treated with a combination of anti-IL-17A and cromolyn sodium, a mast cell membrane stabilizer, showed significantly reduced clinical severity and decreased bone erosion. The findings of the present study suggest that synovial microenvironment-influenced mast cells contribute to RA and may provide a novel mast cell-targeting therapy for RA.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:19:32.712.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yunxuan Lei
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-06 07:28:28	ID requested
1	2024-01-06 23:21:54	announced
⏵ 2	2024-10-22 06:19:33	announced	2024-10-22: Updated project metadata.

Lei Y, Guo X, Luo Y, Niu X, Xi Y, Xiao L, He D, Bian Y, Zhang Y, Wang L, Peng X, Wang Z, Chen G, Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis. Nat Commun, 15(1):113(2024) [pubmed]

10.1038/s41467-023-44304-w;

submitter keyword: RA • Synovial microenvironment • Mast cells • MRGPRX2

Guangjie Chen
contact affiliation	Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine
contact email	chenguangjie@sjtu.edu.cn
lab head
Yunxuan Lei
contact affiliation	Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology
contact email	936241314@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD038584

PRIDE project URI

• PRIDE
  1. PXD038584
     1. Label: PRIDE project
     2. Name: Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis