PXD038567

PXD038567 is an original dataset announced via ProteomeXchange.

Title	Temporal Proteomic and Lipidomic Profiles of Cerulein-Induced Acute Pancreatitis Reveals Novel Insights for Metabolic Alterations in the Disease Pathogenesis
Description	The pathophysiological mechanisms of acute pancreatitis (AP) are complex and have remained a mystery to date, but metabolism is gradually recognized as an important driver of AP onset and development. We used a cerulein-induced AP mouse model to conduct LC-MS/MS based time-course proteomics and lipidomics in order to better understand the underlying metabolic alterations linked with AP. Results showed that a series of significant changes in proteins over time with a boost in expression were enriched in lipase activity, lipoprotein and lipids absorption and transport regulation. Furthermore, 16 proteins associated with lipid metabolism and signaling pathways together with the whole lipid species changing profile led to the vital identification of changing law in glycerides, phosphoglycerides and free fatty acids. In addition to lipid metabolism and regulation associated proteins, several digestive enzymes and adaptive anti-trypsin, stress response, and energy metabolism related proteins showed an increment in abundance. Notably, central carbon and branched chain amino acids metabolism were enhanced during 0-24 h from the first cerulein stimulation. Taken together, this integrated proteomics and lipidomics revealed a novel metabolic insight on metabolites transforming rules that might be relevant to their function and drug targets investigation.
HostingRepository	iProX
AnnounceDate	2022-12-06
AnnouncementXML	Submission_2023-12-06_19:06:04.478.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-05 20:24:24	ID requested
1	2023-03-09 18:19:24	announced
⏵ 2	2023-12-06 19:06:05	announced	2023-12-07: Update information.

Wang R, Wang Y, Tao Y, Hu L, Qiu Q, Pu Q, Yang J, Wang S, Huang Y, Chen X, Zhu P, Yang H, Xia Q, Du D, Temporal Proteomic and Lipidomic Profiles of Cerulein-Induced Acute Pancreatitis Reveal Novel Insights for Metabolic Alterations in the Disease Pathogenesis. ACS Omega, 8(13):12310-12326(2023) [pubmed]

submitter keyword: Proteomics, lipidomics, acute pancreatitis, time-course, phosphoglycerides

Dan Du
contact affiliation	West China Hospital, Sichuan University
contact email	dudan1520@163.com
lab head
Rui Wang
contact affiliation	West China Hospital, Sichuan University
contact email	1036884408@qq.com
dataset submitter

iProX dataset URI