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PXD038555

PXD038555 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMagnetic Transferrin Assay (MTA) as a novel approach for discovering serum exosome derived protein biomarkers in neurological diseases
DescriptionWe developed TF-based MNPs (TF-MNPs) to isolate blood-derived exosome in this study and isolated the blood-derived exosomes of patients with neuroinflammatory diseases, such as dementia, Parkinson’s disease and multiple sclerosis via this strategy and then evaluated the proteomic profiling of these exosomes to screen for a potential candidate biomarker. Blood was collected from 10 patients in each of the three disease groups. Over 800 serum exosome proteins were identified by highly sensitive nanoflow liquid chromatography-tandem mass spectrometry (LC−MS/MS).
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:29:18.091.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHee-Sung Ahn
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-05 06:25:31ID requested
12023-02-19 17:23:02announced
22023-11-14 08:29:20announced2023-11-14: Updated project metadata.
Publication List
Jang YO, Ahn HS, Dao TNT, Hong J, Shin W, Lim YM, Chung SJ, Lee JH, Liu H, Koo B, Kim MG, Kim K, Lee EJ, Shin Y, Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases. Biomater Res, 27(1):12(2023) [pubmed]
Keyword List
submitter keyword: Human, Serum exosome, LC-MSMS, Dementia, Multiple sclerosis, Parkinson, Neurological disease
Contact List
Kyunggon Kim
contact affiliationDepartment of Convergence Medicine, Convergence Medicine Research Center/Biomedical Research Center, Asan Medical Center, Asan Institute for Life Sciences, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
contact emailkkkon1@amc.seoul.kr
lab head
Hee-Sung Ahn
contact affiliationAsan Medical Center
contact emailzaulim3@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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