PXD038542

PXD038542 is an original dataset announced via ProteomeXchange.

Title	Recognition of host-protective immune activation by Mycobacterium tuberculosis
Description	The cytokine interferon-γ is a principal effector of macrophage activation and immune resistance to mycobacterial infection; however, pathogenic mycobacteria are capable of surviving in interferon-γ-activated macrophages by largely unknown mechanisms. We found that interferon-γ specifically bound to pathogenic mycobacteria and enhanced their growth in culture. Proteomic and electron microscopy analyses revealed that interferon-γ directly triggers proliferative activity and virulence phenotype in pathogenic mycobacteria that allow them to survive and grow inside macrophages. These findings suggest that pathogenic mycobacteria may have evolved eukaryotic-like signal transduction mechanisms to recognize host-protective immune activation.
HostingRepository	PRIDE
AnnounceDate	2024-09-05
AnnouncementXML	Submission_2024-09-04_20:55:36.283.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hsin-Yi Wu
SpeciesList	scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Mycobacterium bovis BCG str. Pasteur 1173P2; NCBI TaxID: 410289;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-05 02:58:16	ID requested
⏵ 1	2024-09-04 20:55:36	announced

10.1007/S00018-024-05425-7;

submitter keyword: Mycobacterium tuberculosis, LC-MS/MS

Huynh Tan Hop
contact affiliation	University Center for Bioscience and Biotechnology, National Cheng Kung University
contact email	z11005045@ncku.edu.tw
lab head
Hsin-Yi Wu
contact affiliation	National Taiwan University
contact email	clairewu.wu@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD038542

PRIDE project URI

• PRIDE
  1. PXD038542
     1. Label: PRIDE project
     2. Name: Recognition of host-protective immune activation by Mycobacterium tuberculosis