PXD038542 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Recognition of host-protective immune activation by Mycobacterium tuberculosis |
Description | The cytokine interferon-γ is a principal effector of macrophage activation and immune resistance to mycobacterial infection; however, pathogenic mycobacteria are capable of surviving in interferon-γ-activated macrophages by largely unknown mechanisms. We found that interferon-γ specifically bound to pathogenic mycobacteria and enhanced their growth in culture. Proteomic and electron microscopy analyses revealed that interferon-γ directly triggers proliferative activity and virulence phenotype in pathogenic mycobacteria that allow them to survive and grow inside macrophages. These findings suggest that pathogenic mycobacteria may have evolved eukaryotic-like signal transduction mechanisms to recognize host-protective immune activation. |
HostingRepository | PRIDE |
AnnounceDate | 2024-09-05 |
AnnouncementXML | Submission_2024-09-04_20:55:36.283.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hsin-Yi Wu |
SpeciesList | scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Mycobacterium bovis BCG str. Pasteur 1173P2; NCBI TaxID: 410289; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-12-05 02:58:16 | ID requested | |
⏵ 1 | 2024-09-04 20:55:36 | announced | |
Publication List
Keyword List
submitter keyword: Mycobacterium tuberculosis, LC-MS/MS |
Contact List
Huynh Tan Hop |
contact affiliation | University Center for Bioscience and Biotechnology, National Cheng Kung University |
contact email | z11005045@ncku.edu.tw |
lab head | |
Hsin-Yi Wu |
contact affiliation | National Taiwan University |
contact email | clairewu.wu@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038542
- Label: PRIDE project
- Name: Recognition of host-protective immune activation by Mycobacterium tuberculosis