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PXD038542

PXD038542 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleRecognition of host-protective immune activation by Mycobacterium tuberculosis
DescriptionThe cytokine interferon-γ is a principal effector of macrophage activation and immune resistance to mycobacterial infection; however, pathogenic mycobacteria are capable of surviving in interferon-γ-activated macrophages by largely unknown mechanisms. We found that interferon-γ specifically bound to pathogenic mycobacteria and enhanced their growth in culture. Proteomic and electron microscopy analyses revealed that interferon-γ directly triggers proliferative activity and virulence phenotype in pathogenic mycobacteria that allow them to survive and grow inside macrophages. These findings suggest that pathogenic mycobacteria may have evolved eukaryotic-like signal transduction mechanisms to recognize host-protective immune activation.
HostingRepositoryPRIDE
AnnounceDate2024-09-05
AnnouncementXMLSubmission_2024-09-04_20:55:36.283.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHsin-Yi Wu
SpeciesList scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Mycobacterium bovis BCG str. Pasteur 1173P2; NCBI TaxID: 410289;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-12-05 02:58:16ID requested
12024-09-04 20:55:36announced
Publication List
10.1007/S00018-024-05425-7;
Keyword List
submitter keyword: Mycobacterium tuberculosis, LC-MS/MS
Contact List
Huynh Tan Hop
contact affiliationUniversity Center for Bioscience and Biotechnology, National Cheng Kung University
contact emailz11005045@ncku.edu.tw
lab head
Hsin-Yi Wu
contact affiliationNational Taiwan University
contact emailclairewu.wu@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
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