PXD038514 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Collagen remodeling leads to inflammation-free expansion of periprostatic adipose tissue and promotes prostate cancer progression |
| Description | Periprostatic adipose tissue (PPAT) abundance correlates with prostate cancer progression, but the mechanism remains unexplained. Here, we used a statistical approach to define abundant PPAT by normalizing PPAT volume to prostate volume in a cohort of 351 patients with a linear regression model. Applying this definition, we find tumors specifically from patients with abundant PPAT exhibit several hallmarks of aggressiveness, suggesting that PPAT abundance might be used to improve risk stratification. We show that abundant PPAT expands by adipocyte hypertrophy but this does not result in inflammation. Extensive extracellular matrix remodeling, notably of the collagen network, and decreased expression of mechano-sensing proteins in adipocytes explains this inflammation-free expansion by decreasing the mechanical constraints on the tissue. Moreover, collagen VI degradation in abundant PPAT is associated with production of endotrophin, a matrikine that promotes cancer progression. We find high levels of endotrophin specifically in the urine of patients with abundant PPAT, indicating the clinical relevance of our findings. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-17 |
| AnnouncementXML | Submission_2026-02-17_09:13:17.829.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Manuelle Ducoux-Petit |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-12-02 05:59:57 | ID requested | |
| ⏵ 1 | 2026-02-17 09:13:18 | announced | |
Publication List
Keyword List
| submitter keyword: Periprostatic adipose tissue (PPAT) |
| prostate cancer |
| endotrophin |
| abundant PPAT |
| inflammation |
Contact List
| Odile Burlet-Schiltz |
|---|
| contact affiliation | Team: Proteomics and Mass Spectrometry of Biomolecules Institute of Pharmacology and Structural Biology BP64182 205 route de Narbonne 31077 Toulouse Cedex04 France |
| contact email | Odile.Schiltz@ipbs.fr |
| lab head | |
| Manuelle Ducoux-Petit |
|---|
| contact affiliation | CNRS |
| contact email | manuelle.ducoux@ipbs.fr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD038514 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038514
- Label: PRIDE project
- Name: Collagen remodeling leads to inflammation-free expansion of periprostatic adipose tissue and promotes prostate cancer progression
