PXD038475

PXD038475 is an original dataset announced via ProteomeXchange.

Title	Serum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs
Description	Development and progression of myxomatous mitral valve disease (MMVD) in domestic dogs is unpredictable and pathobiology still unclear. The American College of Veterinary Internal Medicine (ACVIM) perceived that mayor improvement in management of diseased dogs would be timely diagnosis, especially detection of transition from MMVD stage B1 into B2. Thus, in this study we compared by tandem mass tag (TMT) protocol and mass spectrometry (MS) acquired quantitative proteome profiles of serum collected from healthy (control) (N=12) and dogs diagnosed with different stages of naturally occurring MMVD: B1 (N=13), B2 (N=12) and C (N=13). Prior to proteomic analysis dogs were distinguished into experimental categories based on echocardiography results. Serum biochemistry and concentrations of three cardiac biomarkers (galectin-3, suppression of tumorigenicity 2 and asymmetric dimethylarginine) were performed to obtain better characterization of healthy/control group and MMVD cases.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:47:02.179.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dina Rešetar Maslov
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; deaminated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-01 01:38:32	ID requested
1	2023-05-10 13:46:43	announced
⏵ 2	2023-11-14 08:47:04	announced	2023-11-14: Updated project metadata.

Re, š, etar Maslov D, Farka, š V, Rubi, ć I, Kule, š J, Beleti, ć A, Beer Ljubi, ć B, Š, mit I, Mrljak V, Torti M, Serum Proteomic Profiles Reflect the Stages of Myxomatous Mitral Valve Disease in Dogs. Int J Mol Sci, 24(8):(2023) [pubmed]

submitter keyword: myxomatous mitral valve disease, degenerative mitral valve disease, TMT proteomics, dogs, serum

Prof. Vladimir Mrljak
contact affiliation	Internal Diseases Clinic, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
contact email	vmrljak@vef.hr
lab head
Dina Rešetar Maslov
contact affiliation	Faculty of Veterinary Medicine of University of Zagreb
contact email	drmaslov@vef.hr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD038475

PRIDE project URI

• PRIDE
  1. PXD038475
     1. Label: PRIDE project
     2. Name: Serum proteome profiling across different stages of myxomatous mitral valve disease in domestic dogs