PXD038470

PXD038470 is an original dataset announced via ProteomeXchange.

Title	Global Neuropeptidome Profiling in Response to Post-traumatic Stress Disorder in Rat
Description	Post-traumatic stress disorder (PTSD) is a psychiatric disorder that affects the health of a wide range of the population. However, its underlying neurophysiological mechanisms remain unclear due to the limited understanding of neuronal signaling molecules such as neuropeptides. Here, we developed mass spectrometry (MS) based qualitative and quantitative analysis to profile the neuropeptides in the control and predator odor exposure rat PTSD model group. In total, 628 unique neuropeptides can be identified across 5 fear circuitry-related brain regions. Meanwhile, brain region-specific changes of serval neuropeptide families including granin, ProSAAS, opioid peptide, cholecystokinin, and tachykinin can be observed in the PTSD group. Neuropeptides from the same protein precursor were also found to vary in different brain regions. This study reveals for the first time the interaction between neuropeptides and severe stress, providing insights into the molecular mechanism of PTSD and corresponding therapeutic strategy.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_09:14:49.234.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Min Ma
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-12-01 01:14:54	ID requested
⏵ 1	2025-05-06 09:14:50	announced

Wu W, Ma M, Ibarra AE, Lu G, Bakshi VP, Li L, Global Neuropeptidome Profiling in Response to Predator Stress in Rat: Implications for Post-Traumatic Stress Disorder. J Am Soc Mass Spectrom, 34(8):1549-1558(2023) [pubmed]

10.1021/jasms.3c00027;

submitter keyword: LC-MS/MS, neuropeptide, PTSD

lingjun Li
contact affiliation	School of Pharmacy University of Wisconsin 777 Highland Ave. Madison, WI 53705-2222
contact email	lingjun.li@wisc.edu
lab head
Min Ma
contact affiliation	UCSD
contact email	mma58@wisc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD038470

PRIDE project URI

• PRIDE
  1. PXD038470
     1. Label: PRIDE project
     2. Name: Global Neuropeptidome Profiling in Response to Post-traumatic Stress Disorder in Rat