PXD038454
PXD038454 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Large neutral amino acid levels tune perinatal neuronal excitability and survival |
| Description | Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically essential large neutral amino acids (LNAAs), lead to autism, we employed metabolomic profiling to study the metabolic states of the cerebral cortex across different developmental stages. We found that the forebrain undergoes significant metabolic remodeling throughout development, with certain groups of metabolites showing stage-specific changes. But what are the consequences of interfering with this metabolic program? By manipulating Slc7a5 expression in neural cells, we found that the metabolism of LNAAs and lipids are interconnected in the cortex. Deletion of Slc7a5 in neurons perturbs specifically the postnatal metabolic state leading to a shift in lipid metabolism and a stage- and cell-type-specific alteration in neuronal activity patterns, resulting in a long-term circuit dysfunction. |
| HostingRepository | iProX |
| AnnounceDate | 2023-02-09 |
| AnnouncementXML | Submission_2023-02-09_19:56:19.708.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lisa Sophie Knaus |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-28 17:22:17 | ID requested | |
| 1 | 2022-11-28 17:22:30 | announced | |
| ⏵ 2 | 2023-02-09 19:56:20 | announced | 2023-02-10: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: TMT 10plex cortex mouse amino acid SLC7A5 development |
Contact List
| Gaia Novarino | |
|---|---|
| contact affiliation | Insitute of Science and Technology Austria (ISTA) |
| contact email | gaia.novarino@ista.ac.at |
| lab head | |
| Lisa Sophie Knaus | |
| contact affiliation | Insitute of Science and Technology Austria |
| contact email | lisa.sophie.knaus@gmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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