PXD038451
PXD038451 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Urinary complement profile in IgA nephropathy |
| Description | Background and objectives The activated complement profile in IgA nephropathy (IgAN) is still unclear. Our study investigated the profile of urinary complements in IgAN patients and their correlations with clinical and pathological characteristics. Methods Urinary protein abundance was detected by liquid chromatography-tandem mass spectrometry (LC‒MS/MS) in 50 IgAN, 50 membranous nephropathy (MN), and 68 healthy controls (HCs). Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify differentially expressed proteins in IgAN patients. Compared to HC and MN, differentially expressed complement proteins were screened in IgAN patients, and their correlations with laboratory or pathological parameters were analyzed. Then, 7 complement components were validated by enzyme-linked immunosorbent assay (ELISA) in the urine samples of 45 IgAN patients. Results There were 786 differentially expressed proteins between IgAN and HC. KEGG analysis showed that differentia |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-28 |
| AnnouncementXML | Submission_2023-03-15_19:07:43.138.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yong Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-28 03:56:54 | ID requested | |
| ⏵ 1 | 2023-03-15 19:07:43 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: IgA nephropathy, complement, proteomics, histopathology |
Contact List
| Yong Zhang | |
|---|---|
| contact affiliation | West China Hospital, Sichuan Universiyty |
| contact email | nankai1989@foxmail.com |
| lab head | |
| Yong Zhang | |
| contact affiliation | West China Hospital, Sichuan University |
| contact email | nankai1989@foxmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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