PXD038430

PXD038430 is an original dataset announced via ProteomeXchange.

Title	Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor
Description	Previous studies on the biomarkers of pathologic myopia choroidal neovascularization (pmCNV) development merely detected limited types of proteins and provide a meagre illustration of the underlying pathways. Hence, an intact picture of molecular changes in the aqueous humor (AH) of pmCNV patients is lacking. Here, to explore the potential mechanisms and biomarkers of pmCNV, we analyzed the correlation between atrophic (A) lesions and neovascular (N) lesions in a myopic cohort based on the ATN grading system for myopic maculopathy (MM). In a quantitative proteomics test of AH profile of our patients, a significant correlation was found between A and N lesions (R = 0.5753, P < 0.0001). Accordingly, groups were divided into patients without MM, patients with myopic atrophic maculopathy (MAM), and patients with pmCNV (N2a lesion). In proteomics analysis, the existence of GFAP and complement-associated molecules in AH samples of the 3 groups also supported that MAM and pmCNV shared similar characteristics. Analyses of the differentially expressed proteins between the pmCNV group and two controls were performed. We identified several potential biomarkers for pmCNV, including FCN3, GFAP, EGFR, SFRP3, PPP2R1A, SLIT2, and CD248. Taken together, our study provides new insights for further research on pmCNV development.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_07:29:12.241.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xufang Sun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	4800 Proteomics Analyzer

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-26 23:37:13	ID requested
⏵ 1	2024-01-26 07:29:13	announced

Yu H, Zhong Z, Zhao Y, Luo H, Sun J, Wang R, Zhang X, Sun X, Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor. BMC Genomics, 24(1):767(2023) [pubmed]

10.1186/s12864-023-09761-z;

submitter keyword: Proteomic

pathologic myopia

choroidal neovascularization

aqueous humor

GFAP

biomarker.

Sun Xufang
contact affiliation	Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie-fang Road, Wuhan, Hubei Province, China
contact email	sunxufang2016@163.com
lab head
Xufang Sun
contact affiliation	Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie-fang Road, Wuhan, Hubei Province, China
contact email	sunxufang2016@163.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD038430
     1. Label: PRIDE project
     2. Name: Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor