⮝ Full datasets listing

PXD038366

PXD038366 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSpatial proteome map of Cryptosporidium parvum sporozoite
DescriptionCryptosporidium is a leading cause of diarrheal disease in children and an important contributor to early childhood mortality. The parasite invades intestinal epithelial cells and remodels them extensively including building an elaborate interface structure. How this occurs at the molecular level is largely unknown. Here, we generated a whole-cell spatial proteome of the Cryptosporidium sporozoite using the spatial proteomics technology hyperLOPIT. These data in combination with genetic and cell-biological experimentation enabled the discovery of the Cryptosporidium secreted effector proteome, including a new secretory organelle.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:59:51.629.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKonstantin Barylyuk
SpeciesList scientific name: Cryptosporidium parvum Iowa II; NCBI TaxID: 353152; scientific name: Cryptosporidium parvum virus 1; NCBI TaxID: 675060;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-25 07:03:36ID requested
12023-11-14 08:59:52announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Cryptosporidium, small granules, secretion, SPS-MS3, rhoptry, organelle, TMT, Apicomplexa, hyperLOPIT, spatial proteome, dense granules, effectors, microneme
Contact List
Ross F. Waller
contact affiliationDepartment of Biochemistry, University of Cambridge, Cambridge, UK
contact emailrfw26@cam.ac.uk
lab head
Konstantin Barylyuk
contact affiliationDepartment of Biochemistry, University of Cambridge
contact emailkb601@cam.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD038366
PRIDE project URI
Repository Record List
[ + ]