PXD038297

PXD038297 is an original dataset announced via ProteomeXchange.

Title	Interactions of graphene-based materials with the blood-brain barrier
Description	In this work, we performed an in vitro investigation of GRM interactions with the BBB. To this aim,we employed GRMs with different surface chemistry and stability, both murine and human models of increasing complexity, and a portfolio of complementary label-free analytical techniques. The use of label-free strategies allows to avoid the problem of fluorescent tag interference and leaching, which makes the results on the bionano-interactions difficult to interpret.42-43 The workflow developed in this paper is widely applicable to study the translocation of different micro- and nano-materials and represents a valuable method to reduce the more expensive and ethically concerning in vivo biodistribution studies.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:45:35.531.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrea Armirotti
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-23 01:37:53	ID requested
1	2023-05-10 13:50:34	announced
2	2023-11-14 08:47:20	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:45:40	announced	2024-10-22: Updated project metadata.

10.1021/acs.nanolett.3c00377;

Castagnola V, Deleye L, Podest, à A, Jaho E, Loiacono F, Debellis D, Trevisani M, Ciobanu DZ, Armirotti A, Pisani F, Flahaut E, Vazquez E, Bramini M, Cesca F, Benfenati F, Interactions of Graphene Oxide and Few-Layer Graphene with the Blood-Brain Barrier. Nano Lett, 23(7):2981-2990(2023) [pubmed]

submitter keyword: proteomics,graphene, blood-brain barrier

Andrea Armirotti
contact affiliation	Fondazione Istituto Italiano di Tecnologia
contact email	andrea.armirotti@iit.it
lab head
Andrea Armirotti
contact affiliation	Analytical Chemistry Lab, Fondazione Istituto Italiano di Tecnologia
contact email	andrea.armirotti@iit.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD038297

PRIDE project URI

• PRIDE
  1. PXD038297
     1. Label: PRIDE project
     2. Name: Interactions of graphene-based materials with the blood-brain barrier