PXD038293
PXD038293 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Exploration on the Mechanism of Decreased Quality of Aging Oocytes After Ovulation |
| Description | Decreased oocyte developmental potential is an important factor affecting fertility and embryonic development. Increasingly evidence is suggested that the decline in oocyte quality caused by aging after in vitro ovulation is a limiting factor affecting the development of assisted reproductive technologies in humans. However, the key molecular mechanisms underlying the decline in the quality of post-ovulatory aging (postOA) oocytes have not been fully characterized. Here, we obtained the protein profile and transcript profile of in vitro postOA oocytes. Particularly, we found the differential protein enrichment feature, such as RNA decay and chromosome segregation pathway. Moreover, transcriptomics analysis shows that down-regulated transcripts are increased in postOA oocytes in humans and mice. The mRNA-decapping enzyme 1A (DCP1A) as a key factor, influences the abundance of oocyte specific expressed marker protein Y-box-binding protein (YBX2), which leads to instability of maternal mRNA and more prone to de |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-23 |
| AnnouncementXML | Submission_2025-06-20_01:44:03.926.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Li Kong |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-22 19:09:59 | ID requested | |
| 1 | 2025-01-01 19:59:47 | announced | |
| ⏵ 2 | 2025-06-20 01:44:05 | announced | 2025-06-20: Add publication. |
Publication List
| Kong L, Gong Y, Wang Y, Yuan M, Liu W, Zhou H, Meng X, Guo X, Liu Y, Zhou Y, Zhang T, Multi-omics revealed that DCP1A and SPDL1 determine embryogenesis defects in postovulatory ageing oocytes. Cell Prolif, 58(3):e13766(2025) [pubmed] |
Keyword List
| submitter keyword: mouse, oocyte, LC-MS/MS |
Contact List
| Teng Zhang | |
|---|---|
| contact affiliation | Inner Mongolia University |
| contact email | zhangteng428@163.com |
| lab head | |
| Li Kong | |
| contact affiliation | Inner Mongolia University |
| contact email | 17854231149@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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