PXD038293

PXD038293 is an original dataset announced via ProteomeXchange.

Title	Exploration on the Mechanism of Decreased Quality of Aging Oocytes After Ovulation
Description	Decreased oocyte developmental potential is an important factor affecting fertility and embryonic development. Increasingly evidence is suggested that the decline in oocyte quality caused by aging after in vitro ovulation is a limiting factor affecting the development of assisted reproductive technologies in humans. However, the key molecular mechanisms underlying the decline in the quality of post-ovulatory aging (postOA) oocytes have not been fully characterized. Here, we obtained the protein profile and transcript profile of in vitro postOA oocytes. Particularly, we found the differential protein enrichment feature, such as RNA decay and chromosome segregation pathway. Moreover, transcriptomics analysis shows that down-regulated transcripts are increased in postOA oocytes in humans and mice. The mRNA-decapping enzyme 1A (DCP1A) as a key factor, influences the abundance of oocyte specific expressed marker protein Y-box-binding protein (YBX2), which leads to instability of maternal mRNA and more prone to de
HostingRepository	iProX
AnnounceDate	2022-11-23
AnnouncementXML	Submission_2025-01-01_19:59:46.891.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kong Li
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-22 19:09:59	ID requested
⏵ 1	2025-01-01 19:59:47	announced

Dataset with its publication pending

submitter keyword: mouse, oocyte, LC-MS/MS

Zhang Teng
contact affiliation	Inner Mongolia University
contact email	zhangteng428@163.com
lab head
Kong Li
contact affiliation	Inner Mongolia University
contact email	17854231149@163.com
dataset submitter

iProX dataset URI