PXD038288 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Effects of FTY720 on phospho-proteome of leukemic cells |
Description | : FTY720 (Fingolimod) is an immunosuppressive drug approved by FDA for Multiple Sclerosis (MS), that has gained attention as anti-cancer drug, thanks to its ability to disrupt the binding between the onco-protein SET and the tumor- suppressor phosphatase PP2A. We investigated FTY720 induced phospho-proteomic changes on acute myeloid leukemia cell lines carrying KMT2A-transocations. The phospho-proteomic data indicated that FTY720 treatment resulted in the down-regulation of phospho-sites associated to protein serine/threonine kinase activity, chromatin organisation and transcription. The findings support the hypothesis of a feedback loop between SET, PP2A and MYC, whereby FTY720 re-activates PP2A with an overall inhibitory effect on MYC, resulting in cell cycle arrest and apoptosis. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-26 |
AnnouncementXML | Submission_2024-01-26_07:06:15.429.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD038288 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Vinothini Rajeeve |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-11-22 06:00:46 | ID requested | |
⏵ 1 | 2024-01-26 07:06:16 | announced | |
Publication List
10.6019/PXD038288; |
Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT, SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. Oncogene, 42(50):3670-3683(2023) [pubmed] |
10.1038/s41388-023-02840-1; |
Keyword List
submitter keyword: FTY720, PP2A, phosphoproteomics, SET, Fingolimod, AML, LC-MS/MS |
Contact List
Pedro R. Cutillas |
contact affiliation | Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266 |
contact email | p.cutillas@qmul.ac.uk |
lab head | |
Vinothini Rajeeve |
contact affiliation | Centre for Haemato Oncology |
contact email | v.rajeeve@qmul.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD038288 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD038288
- Label: PRIDE project
- Name: Effects of FTY720 on phospho-proteome of leukemic cells