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PXD038288

PXD038288 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEffects of FTY720 on phospho-proteome of leukemic cells
Description: FTY720 (Fingolimod) is an immunosuppressive drug approved by FDA for Multiple Sclerosis (MS), that has gained attention as anti-cancer drug, thanks to its ability to disrupt the binding between the onco-protein SET and the tumor- suppressor phosphatase PP2A. We investigated FTY720 induced phospho-proteomic changes on acute myeloid leukemia cell lines carrying KMT2A-transocations. The phospho-proteomic data indicated that FTY720 treatment resulted in the down-regulation of phospho-sites associated to protein serine/threonine kinase activity, chromatin organisation and transcription. The findings support the hypothesis of a feedback loop between SET, PP2A and MYC, whereby FTY720 re-activates PP2A with an overall inhibitory effect on MYC, resulting in cell cycle arrest and apoptosis.
HostingRepositoryPRIDE
AnnounceDate2024-01-26
AnnouncementXMLSubmission_2024-01-26_07:06:15.429.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD038288
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterVinothini Rajeeve
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-11-22 06:00:46ID requested
12024-01-26 07:06:16announced
Publication List
10.6019/PXD038288;
Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT, SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. Oncogene, 42(50):3670-3683(2023) [pubmed]
10.1038/s41388-023-02840-1;
Keyword List
submitter keyword: FTY720, PP2A, phosphoproteomics, SET, Fingolimod, AML, LC-MS/MS
Contact List
Pedro R. Cutillas
contact affiliationCentre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266
contact emailp.cutillas@qmul.ac.uk
lab head
Vinothini Rajeeve
contact affiliationCentre for Haemato Oncology
contact emailv.rajeeve@qmul.ac.uk
dataset submitter
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Dataset FTP location
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