PXD038288

PXD038288 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Effects of FTY720 on phospho-proteome of leukemic cells
Description	: FTY720 (Fingolimod) is an immunosuppressive drug approved by FDA for Multiple Sclerosis (MS), that has gained attention as anti-cancer drug, thanks to its ability to disrupt the binding between the onco-protein SET and the tumor- suppressor phosphatase PP2A. We investigated FTY720 induced phospho-proteomic changes on acute myeloid leukemia cell lines carrying KMT2A-transocations. The phospho-proteomic data indicated that FTY720 treatment resulted in the down-regulation of phospho-sites associated to protein serine/threonine kinase activity, chromatin organisation and transcription. The findings support the hypothesis of a feedback loop between SET, PP2A and MYC, whereby FTY720 re-activates PP2A with an overall inhibitory effect on MYC, resulting in cell cycle arrest and apoptosis.
HostingRepository	PRIDE
AnnounceDate	2024-01-26
AnnouncementXML	Submission_2024-01-26_07:06:15.429.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD038288
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Vinothini Rajeeve
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-22 06:00:46	ID requested
⏵ 1	2024-01-26 07:06:16	announced

Publication List

10.6019/PXD038288;
Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT, SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. Oncogene, 42(50):3670-3683(2023) [pubmed]
10.1038/s41388-023-02840-1;

10.6019/PXD038288;

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT, SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. Oncogene, 42(50):3670-3683(2023) [pubmed]

10.1038/s41388-023-02840-1;

Keyword List

submitter keyword: FTY720, PP2A, phosphoproteomics, SET, Fingolimod, AML, LC-MS/MS

submitter keyword: FTY720, PP2A, phosphoproteomics, SET, Fingolimod, AML, LC-MS/MS

Contact List

Pedro R. Cutillas
contact affiliation	Centre for Genomics and Computational Biology Barts Cancer Institute Queen Mary, University of London John Vane Science Centre, Charterhouse Square, London EC1M 6BQ Tel: +44 (0)20 7882 8266
contact email	p.cutillas@qmul.ac.uk
lab head
Vinothini Rajeeve
contact affiliation	Centre for Haemato Oncology
contact email	v.rajeeve@qmul.ac.uk
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/01/PXD038288

PRIDE project URI

Repository Record List

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