PXD038281

PXD038281 is an original dataset announced via ProteomeXchange.

Title	Proteomics analysis of the corneal amyloid disaggregation effects by brain chaperone L-PGDS
Description	TGFBIp-related corneal dystrophy (CD) is the most common form of stromal corneal dystrophy. Although CD is a group of inheritable and progressive corneal diseases, non-inheritable cases of corneal amyloid deposition are reported. TGFBIp-CD is characterized by the accumulation of insoluble protein deposits consisting smaller proteolytic fragments of TGFBIp in the corneal tissues, eventually leading to progressive corneal opacity. Maximum density of these aggregates is in the corneal center implicating the local absence of amyloid controlling factors. Currently, no other treatment options are available besides the surgical replacement of the affected corneal tissues with a donor’s cornea. Here we show that neuroprotective ATP-independent amyloid β chaperone L-PGDS abundant in cerebrospinal fluid but absent in the corneal tissues can effectively disaggregate amyloids in vitro and in the surgically excised human cornea of patients with TGFBIp-CD.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:45:33.445.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kimberly Jia Yi Low
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-22 03:33:07	ID requested
1	2023-05-10 13:41:45	announced
2	2023-11-14 08:46:57	announced	2023-11-14: Updated project metadata.
⏵ 3	2024-10-22 05:45:34	announced	2024-10-22: Updated project metadata.

10.1038/s42003-023-04725-1;

Low JYK, Shi X, Anandalakshmi V, Neo D, Peh GSL, Koh SK, Zhou L, Abdul Rahim MK, Boo K, Lee J, Mohanram H, Alag R, Mu Y, Mehta JS, Pervushin K, Release of frustration drives corneal amyloid disaggregation by brain chaperone. Commun Biol, 6(1):348(2023) [pubmed]

ProteomeXchange project tag: Human Proteome Project

submitter keyword: TGFBI-related corneal dystrophy, L-PGDS, amyloid disaggregation, corneal dystrophy, ATP independent

Konstantin Pervushin
contact affiliation	Assoc Prof Konstantin Pervushin SCHOOL OF BIOLOGICAL SCIENCES, Nanyang Technological University
contact email	kpervushin@ntu.edu.sg
lab head
Kimberly Jia Yi Low
contact affiliation	Nanyang Technological University
contact email	kimb0017@e.ntu.edu.sg
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD038281

PRIDE project URI

• PRIDE
  1. PXD038281
     1. Label: PRIDE project
     2. Name: Proteomics analysis of the corneal amyloid disaggregation effects by brain chaperone L-PGDS