PXD038265

PXD038265 is an original dataset announced via ProteomeXchange.

Title	Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics
Description	Untargeted proteomics based precise diagnosis and typing of amyloid deposits are crucial for guiding patient management. However, it may not be suitable for early-stage renal amyloidosis with minor damages. Here, we aimed to develop parallel reaction monitoring (PRM)-based targeted proteomics to achieve high sensitivity and specificity in identifying early-stage renal immunoglobulin-derived amyloidosis.This study demonstrates that the utility of these prioritized peptides in PRM-based targeted proteomics ensure highly sensitive and reliable for identifying early-stage renal amyloidosis. Owing to the development and clinical application of this method, rapid acceleration of the early diagnosis, and typing of renal amyloidosis is expected.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_07:58:31.467.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuan Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-22 02:44:43	ID requested
1	2023-03-10 13:11:38	announced
⏵ 2	2023-11-14 07:58:32	announced	2023-11-14: Updated project metadata.

Li Y, Zhang Y, Zhou X, Xue X, Wang M, Kang D, Zhou Y, Hu R, Quan S, Xing G, Yang J, Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics. BMC Nephrol, 24(1):50(2023) [pubmed]

submitter keyword: laser microdissection,amyloidosis, kidney, parallel reaction monitoring, targeted proteomics

Guolan Xing
contact affiliation	Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
contact email	xgl@zzu.edu.cn
lab head
Yuan Li
contact affiliation	the First Affiliated Hospital of Zhengzhou University
contact email	yuanlifsc@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD038265

PRIDE project URI

• PRIDE
  1. PXD038265
     1. Label: PRIDE project
     2. Name: Precise diagnosis and typing of early-stage renal immunoglobulin-derived amyloidosis by label-free quantification of parallel reaction monitoring-based targeted proteomics