PXD038248

PXD038248 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MS/MS-based Proteomics Approach for the Identification of Candidate Serum Biomarkers in Patients with Narcolepsy Type 1
Description	The study is based on the identification of serum protein biomarkers for NT 1. A total of 27 serum samples were collected (16 NT 1 and 11 controls), the altered expression levels of low-abundant proteins (DEPs) associated with narcolepsy type 1 was investigated by comparing the proteomes of the two sample cohorts. DEPs that are revealed to be most related to NT 1 pathogenesis and have high levels of fold changes were further targeted and validated by LC-PRM-MS. Then, the effects of the DEPs were explored by system biology analysis.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:46:13.233.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD038248
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Akeem Sanni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF; LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-21 16:43:57	ID requested
1	2023-05-10 10:00:37	announced
⏵ 2	2023-11-14 08:46:20	announced	2023-11-14: Updated project metadata.

Publication List

Sanni A, Goli M, Zhao J, Wang J, Barsa C, El Hayek S, Talih F, Lanuzza B, Kobeissy F, Plazzi G, Moresco M, Mondello S, Ferri R, Mechref Y, LC-MS/MS-Based Proteomics Approach for the Identification of Candidate Serum Biomarkers in Patients with Narcolepsy Type 1. Biomolecules, 13(3):(2023) [pubmed]
10.6019/PXD038248;

Sanni A, Goli M, Zhao J, Wang J, Barsa C, El Hayek S, Talih F, Lanuzza B, Kobeissy F, Plazzi G, Moresco M, Mondello S, Ferri R, Mechref Y, LC-MS/MS-Based Proteomics Approach for the Identification of Candidate Serum Biomarkers in Patients with Narcolepsy Type 1. Biomolecules, 13(3):(2023) [pubmed]

10.6019/PXD038248;

Keyword List

submitter keyword: narcolepsy type 1,LC-MS/MS, and orexin/hypocretin., differentially expressed proteins (DEPs), Acute phase response signaling, autoimmunity, pathophysiology, human leukocyte antigen

submitter keyword: narcolepsy type 1,LC-MS/MS, and orexin/hypocretin., differentially expressed proteins (DEPs), Acute phase response signaling, autoimmunity, pathophysiology, human leukocyte antigen

Contact List

Yehia Mechref
contact affiliation	Texas Tech University
contact email	yehia.mechref@ttu.edu
lab head
Akeem Sanni
contact affiliation	Texas Tech University
contact email	aksanni@ttu.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD038248
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD038248

PRIDE project URI

Repository Record List

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