PXD038161

PXD038161 is an original dataset announced via ProteomeXchange.

Title	Ureter proteomics analysis following stent placement and removal in a porcine model
Description	Symptoms including pain and discomfort commonly present during ureteral stenting is not well understood. We investigated global changes in ureters at the transcriptional, translational, and functional levels while stents are indwelling and following removal and recovery using a porcine model. Polaris stents (6Fr, Boston Scientific, Natick, MA) were cystoscopically inserted with placement confirmed using fluoroscopy. For proteomics samples, ureters were stented for 14 days and recovered for 7 days and each pig was stented unilaterally so that the contralateral unstented kidney and ureter served as an internal control.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:47:13.106.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hans Adomat
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-15 07:42:22	ID requested
1	2023-05-10 13:59:48	announced
⏵ 2	2023-11-14 08:47:15	announced	2023-11-14: Updated project metadata.

Reicherz A, Eltit F, Scotland K, Almutairi K, Bell R, Mojtahedzadeh B, Cox M, Chew B, Lange D, Indwelling stents cause severe inflammation and fibrosis of the ureter via urothelial-mesenchymal transition. Sci Rep, 13(1):5492(2023) [pubmed]

submitter keyword: proteomics, TMT, lc-ms,porcine, ureter, stent

Dirk Lange
contact affiliation	Urologic Sciences, University of British Columbia
contact email	dirk.lange@ubc.ca
lab head
Hans Adomat
contact affiliation	Vancouver Prostate Centre
contact email	hadomat@prostatecentre.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD038161

PRIDE project URI

• PRIDE
  1. PXD038161
     1. Label: PRIDE project
     2. Name: Ureter proteomics analysis following stent placement and removal in a porcine model