PXD038155

PXD038155 is an original dataset announced via ProteomeXchange.

Title	Multi-omics characterization of response to PD-1 inhibitors in advanced melanoma
Description	Immunotherapy improves the survival of patients with advanced melanoma, 40% of whom become long-term responders. However, not all patients respond to immunotherapy. Further knowledge about the processes involved in response and resistance to immunotherapy is still needed. In this study, clinical paraffin samples from fifty-two advanced melanoma patients treated with anti-PD1 inhibitors were assessed by high-throughput proteomics and RNA-seq. The obtained proteomics and transcriptomics data were analyzed using network analyses based on probabilistic graphical models to identify those biological processes involved in response to immunotherapy. Additionally, proteins related to overall survival were studied.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:05:28.419.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antje Dittmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-15 07:30:36	ID requested
1	2023-09-25 01:10:28	announced
⏵ 2	2023-11-14 09:05:31	announced	2023-11-14: Updated project metadata.

Trilla-Fuertes L, G, á, mez-Pozo A, Prado-V, á, zquez G, L, ó, pez-Vacas R, Soriano V, Garicano F, Lecumberri MJ, Rodr, í, guez de la Borbolla M, Majem M, P, é, rez-Ruiz E, Gonz, á, lez-Cao M, Oramas J, Magdaleno A, Fra J, Mart, í, n-Carnicero A, Corral M, Pu, é, rtolas T, Ramos-Ruiz R, Dittmann A, Nanni P, Fresno Vara J Á, Espinosa E, Multi-omics Characterization of Response to PD-1 Inhibitors in Advanced Melanoma. Cancers (Basel), 15(17):(2023) [pubmed]

submitter keyword: omics, FFPE, immunotherapy,PD-1 inhibitor, melanoma

Enrique Espinosa
contact affiliation	Medical Oncology Service, Hospital Universitario La Paz, Madrid, Spain
contact email	eespinosa00@hotmail.com
lab head
Antje Dittmann
contact affiliation	ETH
contact email	antje.dittmann@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD038155

PRIDE project URI

• PRIDE
  1. PXD038155
     1. Label: PRIDE project
     2. Name: Multi-omics characterization of response to PD-1 inhibitors in advanced melanoma