PXD038152

PXD038152 is an original dataset announced via ProteomeXchange.

Title	Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma
Description	Lenvatinib is the FDA-approved targeted drug for advanced hepatocellular carcinoma (HCC), but the efficacy is modest due to drug resistance. Tumor kinome re-wiring governs drug resistance in resistant cancer cells, which is an obstacle for efficient cancer therapy. Therefore, identification the kinases critical for this rewiring process in HCC is crucial.This study reveals the new role of CDK6 and its mechanistic insight in regulation of cancer stemness and drug resistance. These results support the combination treatment of lenvatinib with palbociclib for advanced HCC patients. Further studies will optimize patient target selection and identify the best treatment combinations.
HostingRepository	PRIDE
AnnounceDate	2023-09-29
AnnouncementXML	Submission_2023-09-29_01:24:44.334.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD038152
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	YangYang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-15 07:26:33	ID requested
⏵ 1	2023-09-29 01:24:44	announced

10.6019/PXD038152;

ProteomeXchange project tag: Cancer (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: beta-catenin, cancer stemness, HCC, CDK6, lenvatinib

Terence Kin WahLee
contact affiliation	Department of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University
contact email	terence.kw.lee@polyu.edu.hk
lab head
YangYang
contact affiliation	The Hong Kong Polytechnic University
contact email	yangss.yang@connect.polyu.hk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD038152

PRIDE project URI

• PRIDE
  1. PXD038152
     1. Label: PRIDE project
     2. Name: Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma