PXD038105

PXD038105 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	LC-MS/MS of HNE-apoE3 and HNE-apoE4
Description	The overall goal of our study is to understand the effect of HNE modification on the structure and function of apolipoprotein E3 (apoE3) and apoE4, which play a critical role in brain cholesterol homeostasis. Immunoblots indicated HNE modification of recombinant apoE3 and apoE4 with a major band at ~36 kDa, while LC-MS/MS analysis revealed modification of H140 and H299 in both, and additionally at C112 in apoE3.
HostingRepository	PRIDE
AnnounceDate	2024-08-09
AnnouncementXML	Submission_2024-08-09_05:09:13.684.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD038105
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Vas Narayanaswami
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion Lumos; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-11 09:03:00	ID requested
⏵ 1	2024-08-09 05:09:14	announced

Publication List

10.6019/PXD038105;
10.1111/febs.16729;
Abeer MI, Abdulhasan A, Haguar Z, Narayanaswami V, Isoform-specific modification of apolipoprotein E by 4-hydroxynonenal: protective role of apolipoprotein E3 against oxidative species. FEBS J, 290(11):3006-3025(2023) [pubmed]

10.6019/PXD038105;

10.1111/febs.16729;

Abeer MI, Abdulhasan A, Haguar Z, Narayanaswami V, Isoform-specific modification of apolipoprotein E by 4-hydroxynonenal: protective role of apolipoprotein E3 against oxidative species. FEBS J, 290(11):3006-3025(2023) [pubmed]

Keyword List

submitter keyword: HNE,ApoE3, ApoE4

submitter keyword: HNE,ApoE3, ApoE4

Contact List

Vas Narayanaswami
contact affiliation	Professor of Biochemistry PD/PI CSULB NIH T34 MARC U*STAR Program Department of Chemistry and Biochemistry California State University, Long Beach Long Beach, CA 90840
contact email	Vas.Narayanaswami@csulb.edu
lab head
Vas Narayanaswami
contact affiliation	Professor of Biochemistry PD/PI CSULB NIH T34 MARC U*STAR Program Department of Chemistry and Biochemistry California State University, Long Beach Long Beach, CA 90840
contact email	Vas.Narayanaswami@csulb.edu
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD038105

PRIDE project URI

Repository Record List

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