PXD038036
PXD038036 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Gut microbiota dysbiosis rewires host mRNA m6A epitranscriptomic landscape via cholic acid metabolism |
| Description | Gut microbiota and their metabolites influence host gene expression and physiological status through diverse mechanisms. Here we investigate how gut microbiota and their metabolites impact host′s mRNA m6A epitranscriptome in various antibiotic-induced microbiota dysbiosis models. With multi-omics analysis, we find that the imbalance of gut microbiota can rewire host mRNA m6A epitranscriptomic profiles in brain, liver and intestine. We further explore the underlying mechanisms regulating host mRNA m6A methylome by depleting the microbiota with ampicillin. Metabolomic profiling shows that cholic acids are the main down-regulated metabolites with Firmicutes as the most significantly reduced genus in ampicillin-treated mice comparing to untreated mice. Fecal microbiota transplantations in germ-free mice and metabolites supplementations in cells verify that cholic acids are associated with host mRNA m6A epitranscriptomic rewiring. Collectively, this study employs an integrative multi-omics analysis to demonstrate the impact of gut microbiota dysbiosis on host mRNA m6A epitranscriptomic landscape via cholic acid metabolism. |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-08 |
| AnnouncementXML | Submission_2024-12-25_18:18:51.525.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Meng Yang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-11-07 22:50:45 | ID requested | |
| ⏵ 1 | 2024-12-25 18:18:51 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Gut microbiota, m6A epitranscriptomic, Proteomics |
Contact List
| Xiaoyun Wang | |
|---|---|
| contact affiliation | South China Normal University |
| contact email | wangxy@scnu.edu.cn |
| lab head | |
| Meng Yang | |
| contact affiliation | South China Normal University |
| contact email | mantouym@outlook.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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