PXD038034

PXD038034 is an original dataset announced via ProteomeXchange.

Title	Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
Description	In this project, SILAC-based quantitative proteomics approach was applied for phosphoproteomics analysis. The light samples were treated with ddH2O as control group, and the medium samples labeled by 2D2 of lysine (K4) and 13C6 of arginine (R6) were treated with 2DG, while the heavy samples labeled by 13C615N2 of lysine (K8) and 13C615N4 of arginine (R10) were treated with 2DG in the presence of PPP6C knockdown. The peptides were analyzed by Orbitrap fusion instrument. Raw data was searched by MaxQuant software (version 1.6.6.0) against uniport human database.
HostingRepository	iProX
AnnounceDate	2022-11-08
AnnouncementXML	Submission_2023-12-21_22:18:56.022.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bingbing Hao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-07 18:18:01	ID requested
1	2022-11-07 18:18:19	announced
⏵ 2	2023-12-21 22:18:56	announced	2023-12-22: Update publication information.

Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH, Tan M, Zhao B, Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha. Mol Cell, 82(24):4700-4711.e12(2022) [pubmed]

submitter keyword: AMPK, phosphoproteomics

Minjia Tan
contact affiliation	Shanghai Institute of Materia Medica
contact email	mjtan@simm.ac.cn
lab head
Bingbing Hao
contact affiliation	Shanghai Institute of Materia Medica
contact email	haobchens@163.com
dataset submitter

iProX dataset URI