PXD037974

PXD037974 is an original dataset announced via ProteomeXchange.

Title	Identification of lysine salicylation as a novel mechanism of action of aspirin
Description	Aspirin, one of most famous old drugs, can exert its functions through non-covalent inhibition and covalent acetylation (N-acetylation and O-acetylation) of protein targets. Here we identified lysine salicylation (Ksa) as a novel mechanism of action of aspirin in cell lines and mice. Unexpectedly, we found that aspirin treatment resulted in a reduction in glycolysis, in which the conversion of fructose-1,6-bisphosphate (FBP) to glyceraldehyde 3-phosphate (GAP) was significantly inhibited. Mechanistically, the deceased FBP turnover was unrelated or partially related to the changes in ALDOA itself or its acetylation. Instead, aspirin treatment increased cellular salicyl-CoA which salicylated ALDOA at Lys13 and Lys42, leading to reduced ALDOA activity and FBP to GAP transformation. Collectively, the discovery of a new mode of action for aspirin may expand its applications in the biomedical field.
HostingRepository	iProX
AnnounceDate	2022-11-07
AnnouncementXML	Submission_2022-11-07_00:40:40.794.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanqiu Gong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-07 00:30:28	ID requested
⏵ 1	2022-11-07 00:40:41	announced

Dataset with its publication pending

submitter keyword: Aspirin, lysine salicylation, ALDOA

Lunzhi Dai
contact affiliation	Sichuan University
contact email	lunzhi.dai@scu.edu.cn
lab head
Yanqiu Gong
contact affiliation	Sichuan University
contact email	niqiu.er@163.com
dataset submitter

iProX dataset URI