PXD037973
PXD037973 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteolysis-assisted cyclization facilitates site-centric target deconvolution of isothiocyanates |
Description | Here we report an unexpected chemistry through which ITC-protein adduct forms a stable N-terminal dihydrothiazole peptide adduct during proteolysis. This proteolysis-assisted cyclization (PAC) reaction can be harnessed for developing affinity-based and activity-based chemoproteomic methods to site-specifically profile targets of ITCs. |
HostingRepository | iProX |
AnnounceDate | 2022-11-07 |
AnnouncementXML | Submission_2022-11-07_00:19:43.704.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jingyang He |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X; Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-11-07 00:12:55 | ID requested | |
⏵ 1 | 2022-11-07 00:19:44 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Isothiocyanates, N-terminal dihydrothiazole peptide adduct |
Contact List
Jing Yang | |
---|---|
contact affiliation | National Center for Protein Sciences (PHOENIX, Beijing) |
contact email | yangjing@ncpsb.org.cn |
lab head | |
Jingyang He | |
contact affiliation | National Center for Protein Sciences (PHOENIX, Beijing) |
contact email | jingyang310047@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |