PXD037955

PXD037955 is an original dataset announced via ProteomeXchange.

Title	Immunological and Metabolic Characteristics of the Omicron Variants Infection
Description	The Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants infection. We found Omicron resisted to neutralizing antibody targeting receptor binding domain (RBD) of wild-type SARS-CoV-2. Omicron could not be neutralized by sera of Corona Virus Disease 2019 (COVID-19) convalescent individuals who were infected with the Delta variant. Through mass spectrometry on MHC-bound peptidomes, we found that the spike protein of the Omicron variants could generate additional CD8+ T cell epitopes, compared with Delta. These epitopes could induce robust CD8+ T cell responses. Moreover, we found booster vaccination increased the cross-memory CD8+ T cell responses against Omicron. Metabolic regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted memory T cell responses. Consistently, a higher fraction of memory CD8+ T cells were found in Omicron stimulated peripheral blood mononuclear cells (PBMCs). In addition, CD147 was also a receptor for the Omicron variants, and CD147 antibody inhibited infection of Omicron. CD147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar pneumonia. Taken together, our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:42:20.052.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kun Wang
SpeciesList	scientific name: Cercopithecus aethiops (Green monkey) (Grivet); NCBI TaxID: 9534;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro 2; Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-04 09:08:51	ID requested
1	2023-03-11 03:42:58	announced
⏵ 2	2023-11-14 08:42:25	announced	2023-11-14: Updated project metadata.

Geng J, Yang X, Wang K, Wang K, Chen R, Chen ZN, Qin C, Wu G, Wang Y, Xu K, Du P, Liu J, Chen S, Zhang T, Sun X, Guo T, Shi Y, Zhang Z, Wei D, Lin P, Wang Q, Yuan J, Qu J, Zou J, Liu Y, Lu H, Zhu P, Bian H, Chen L, Immunological and metabolic characteristics of the Omicron variants infection. Signal Transduct Target Ther, 8(1):42(2023) [pubmed]

submitter keyword: Cos7 Cell;HLA class Ι;Hepatitis B virus and SARS-CoV-2 peptides

Liang Chen
contact affiliation	School of Medicine, Shanghai University, Shanghai 200444, China.
contact email	lchen@shu.edu.cn
lab head
Kun Wang
contact affiliation	Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University
contact email	827950581@qq.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD037955
     1. Label: PRIDE project
     2. Name: Immunological and Metabolic Characteristics of the Omicron Variants Infection