PXD037922

PXD037922 is an original dataset announced via ProteomeXchange.

Title	DRAK2 alters IL-2 sensitivity and Treg development
Description	Drak2¬-deficient (Drak2-/-) mice are resistant to multiple models of autoimmunity, yet effectively eliminate pathogens and tumors. Thus, DRAK2 is an ideal target to treat autoimmune diseases. However, the mechanisms by which DRAK2 contributes to autoimmunity, particularly type 1 diabetes (T1D), remain unresolved. Our data indicate that DRAK2 contributes to autoimmunity in multiple ways by regulating thymic Treg development and by impacting the sensitivity of conventional T cells to Treg-mediated suppression.
HostingRepository	PRIDE
AnnounceDate	2023-02-09
AnnouncementXML	Submission_2023-02-09_03:23:34.679.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AshutoshMishra
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-11-03 04:51:48	ID requested
⏵ 1	2023-02-09 03:23:35	announced

Dataset with its publication pending

submitter keyword: regulatory T cells,Type 1 diabetes, T cells, tolerance, thymus, IL-2

Maureen A.McGargill
contact affiliation	Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
contact email	Maureen.McGargill@STJUDE.ORG
lab head
AshutoshMishra
contact affiliation	St. Jude Children's Research Hospital
contact email	ashutosh.mishra@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/02/PXD037922

PRIDE project URI

• PRIDE
  1. PXD037922
     1. Label: PRIDE project
     2. Name: DRAK2 alters IL-2 sensitivity and Treg development