PXD037900 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomics of Human Breast-TMG LC-MS/MS |
Description | Type I, II, III and V collagens were commonly identified in human, pig, and mouse breast ECM. Mammary epithelial cells were able to form acini on certain types or combinations of the four collagens at normal breast tissue stiffness levels. Comparison of the collagen species in mouse normal breast and breast tumor ECM revealed common and distinct sets of collagens within the two types of tissues. Elevated collagen type I alpha 1 chain expression was found in human breast cancers. Collagen type XXV alpha 1 chain was identified in mouse breast tumors but not in normal breast tissues. Our data provide insights into modeling human breast pathophysiological structures and functions using native tissue-derived hydrogels and potential contributions of different collagen types or their monomers in breast cancer development. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:39:32.065.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD037900 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Weimin Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Agilent instrument model |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-11-03 04:10:27 | ID requested | |
1 | 2023-03-11 00:29:18 | announced | |
⏵ 2 | 2023-11-14 08:39:32 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keller CR, Ruud KF, Martinez SR, Li W, Identification of the Collagen Types Essential for Mammalian Breast Acinar Structures. Gels, 8(12):(2022) [pubmed] |
10.6019/PXD037900; |
Keyword List
submitter keyword: Tissue Matrix Gel,Human Breast, LC-MS/MS |
Contact List
Weimin Li |
contact affiliation | Washington State University |
contact email | weimin.li@wsu.edu |
lab head | |
Weimin Li |
contact affiliation | Washington State University Spokane |
contact email | weimin.li@wsu.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD037900 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD037900
- Label: PRIDE project
- Name: Proteomics of Human Breast-TMG LC-MS/MS