PXD037868
PXD037868 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Liver proteomic reveals the key proteins involved in host immune response to sepsis |
| Description | Sepsis is a serious infection-induced response in the host,which can lead to organ dysfunction. It is of great importance to unravel the relationship between sepsis and host immune response and its mechanisms of action. Liver is one of the most vulnerable organs in sepsis, however, the specific pathogenesis of septic liver injury has not been well understood at the protein level. Here, a TMT-based proteomic analysis for liver was performed in the septic rat model. Compared to the healthy control group,the differentially expressed proteins (DEPs) were the most significantly enriched into the complement and coagulation cascades and metabolic pathways. And the DEPs may serve as clinically potential treatment targets for septic liver injury. |
| HostingRepository | iProX |
| AnnounceDate | 2022-11-15 |
| AnnouncementXML | Submission_2023-06-06_23:41:21.588.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yingying Chen |
| SpeciesList | scientific name: Rattus norvegicus; NCBI TaxID: 10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-10-31 20:11:32 | ID requested | |
| 1 | 2022-10-31 20:12:52 | announced | |
| 2 | 2022-11-16 19:11:46 | announced | 2022-11-17: Update information. |
| ⏵ 3 | 2023-06-06 23:41:22 | announced | 2022-11-17: Update information. 2023-06-07: Update publication information. |
Publication List
| Chen Y, Gong H, Tang D, Yu L, Long S, Zheng B, Luo D, Cai A, Liver proteomic analysis reveals the key proteins involved in host immune response to sepsis. PeerJ, 11():e15294(2023) [pubmed] |
Keyword List
| submitter keyword: proteomic analysis, rat model, sepsis |
Contact List
| Dixian Luo | |
|---|---|
| contact affiliation | Huazhong University of Science and Technology Union Shenzhen Hospital |
| contact email | luodixian_2@163.com |
| lab head | |
| Yingying Chen | |
| contact affiliation | Huazhong University of Science and Technology Union Shenzhen Hospital |
| contact email | 125415691@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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