PXD037856

PXD037856 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope
Description	Unlike other signaling proteins, cellular stimulation does not induce nuclear AKT accumulation. While AKT1 is cytoplasmic, shifting to the plasma membrane upon stimulation, AKT2 is mainly nuclear. AKT3 in cancer cells is constitutively active at the nuclear envelope, where it phosphorylates TSC2 and promotes proliferation.
HostingRepository	PRIDE
AnnounceDate	2022-12-11
AnnouncementXML	Submission_2022-12-10_23:22:47.641.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TamarZiv
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-31 09:16:05	ID requested
⏵ 1	2022-12-10 23:22:47	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: nuclear envelope,AKT3, phosphorylation

submitter keyword: nuclear envelope,AKT3, phosphorylation

Contact List

Prof. RonySeger
contact affiliation	Department of Immunology & Regenerative Biology Weizmann Institute of Science Rehovot, 7610001, Israel
contact email	rony.seger@weizmann.ac.il
lab head
TamarZiv
contact affiliation	Technion
contact email	tamarz@technion.ac.il
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD037856
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/12/PXD037856

PRIDE project URI

Repository Record List

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