PXD037853

PXD037853 is an original dataset announced via ProteomeXchange.

Title	17 -estradiol impedes aortic root dilation and rupture in male Marfan mice
Description	Thoracic aortic aneurysms have a higher prevalence in male patients compared to female patients. Marfan syndrome causes a hereditary form of TAA with dilation of the aortic root. Male patients with Marfan syndrome are more likely than women to have aortic dilation and dissection and mouse models of Marfan syndrome demonstrate larger aortic roots in males compared to females even after adjustment for body size. Similar sex disparities are present in patients and models of abdominal aortic aneurysms where estrogen has been demonstrated to attenuate aneurysm formation perhaps through anti-inflammatory mechanisms. In this study we demonstrate the effects of estrogen on aortic dilation and rupture in a Marfan mouse model and we investigate if these effects operate through suppression of complement components of the immune system.
HostingRepository	PRIDE
AnnounceDate	2024-02-14
AnnouncementXML	Submission_2024-02-14_09:45:13.490.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sarah Parker
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-10-31 09:14:53	ID requested
⏵ 1	2024-02-14 09:45:14	announced

Saddic L, Escopete S, Zilberberg L, Kalsow S, Gupta D, Eghbali M, Parker S, -Estradiol Impedes Aortic Root Dilation and Rupture in Male Marfan Mice. Int J Mol Sci, 24(17):(2023) [pubmed]

10.3390/ijms241713571;

submitter keyword: Marfan Syndrome, Estrogen, Sex Differences, Aneurysm

Sarah Parker
contact affiliation	Assistant Professor, Cedars-Sinai Medical Center, Cardiology
contact email	sarah.parker@cshs.org
lab head
Sarah Parker
contact affiliation	Cedars-Sinai Medical Center
contact email	sarah.parker@cshs.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD037853

PRIDE project URI

• PRIDE
  1. PXD037853
     1. Label: PRIDE project
     2. Name: 17 -estradiol impedes aortic root dilation and rupture in male Marfan mice